Matrix Metalloproteinase 13 Is Associated with Age-Related Choroidal Neovascularization [PDF]
Antioxidants, 2023 Age-related macular degeneration (AMD) is a leading cause of severe vision loss in older individuals in developed countries. Despite advances in our understanding of AMD, its pathophysiology remains poorly understood.
Jorge González-Zamora +8 more
doaj +5 more sources
Differential expression of matrix metalloproteinase-13 in association with invasion of breast cancer [PDF]
Contemporary Oncology, 2016 Matrix metalloproteinase-13 (MMP-13) has a potential role in tumour invasion and metastasis. However, its relevance to the prognosis of human breast cancer is poorly understood.
Manas Kotepui +5 more
doaj +6 more sources
Potential Value of Matrix Metalloproteinase-13 as a Biomarker for Osteoarthritis [PDF]
Frontiers in Surgery, 2021 Background: Emerging knowledge has highlighted the role of matrix metalloproteinase (MMP)-13 in osteoarthritis (OA); however, the suitability of MMP-13 as a biomarker for OA remains unclear.
Xing Xin +16 more
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Interleukin 36 receptor-inducible matrix metalloproteinase 13 mediates intestinal fibrosis [PDF]
Frontiers in Immunology, 2023 BackgroundFibrostenotic disease is a common complication in Crohn’s disease (CD) patients hallmarked by transmural extracellular matrix (ECM) accumulation in the intestinal wall.
Kristina Koop +19 more
doaj +2 more sources
(2-Aminobenzothiazole)-Methyl-1,1-Bisphosphonic Acids: Targeting Matrix Metalloproteinase 13 Inhibition to the Bone [PDF]
Pharmaceuticals, 2021 Matrix Metalloproteinases (MMPs) are a family of secreted and membrane-bound enzymes, of which 24 isoforms are known in humans. These enzymes degrade the proteins of the extracellular matrix and play a role of utmost importance in the physiological ...
Antonio Laghezza +6 more
doaj +2 more sources
Regulation and Function of Matrix Metalloproteinase-13 in Cancer Progression and Metastasis. [PDF]
Cancers (Basel), 2022 Matrix metalloproteinase-13 (MMP-13) is a member of the Matrix metalloproteinases (MMPs) family of endopeptidases. MMP-13 is produced in low amounts and is well-regulated during normal physiological conditions. Its expression and secretion are, however, increased in various cancers, where it plays multiple roles in tumour progression and metastasis. As
Li S, Pritchard DM, Yu LG.
europepmc +3 more sources
Serum matrix metalloproteinase-13 as a diagnostic biomarker for cutaneous squamous cell carcinoma [PDF]
BMC Cancer, 2021 Background A significant proportion of newly diagnosed patients with cutaneous squamous cell carcinoma (cSCC) have metastasis and eventually die of the disease, necessitating the exploration of novel biomarkers for early detection of cSCC aggressiveness,
Hui Wang +6 more
doaj +2 more sources
Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis. [PDF]
PLoS ONE, 2013 Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by excessive deposition of extracellular matrix (ECM).We investigated the regulation of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in lung fibrosis.MMP and TIMP ...
Takwi Nkyimbeng +8 more
doaj +5 more sources
Immunohistochemical analysis of matrix metalloproteinase-13 in human caries dentin
European Journal of Histochemistry, 2014 The immunoexpression profile of matrix metalloproteinase-13 was investigated for the first time in dentin of human caries and healthy teeth. Twelve permanent premolars (10 caries and 2 sound) were decalcified in ethylenediaminetetraacetic acid and ...
C. Loreto +4 more
doaj +4 more sources
Matrix metalloproteinase 13, a new target for therapy in Alzheimer's disease. [PDF]
Genes Dis, 2019 Alzheimer's disease (AD), the most common neurodegenerative disorder, affects millions of people worldwide. In a recent publication, Guo-Jun Chen and colleagues highlight the role of matrix metalloproteinase (MMP) 13 (also called Collagenase 3) in AD pathogenesis through regulating BACE1, 1 a rate-limiting enzyme for β-amyloid (Aβ ...
Paumier JM, Thinakaran G.
europepmc +3 more sources