Results 21 to 30 of about 73,669,415 (286)

Comparison of Elaeagnus angustifolia L. extract and quercetin on mouse model of knee osteoarthritis

Journal of Ayurveda and Integrative Medicine, 2022
Osteoarthritis (OA) is the most commonly observed arthritic disease causing severe pain and impairing patient's quality of life. This study aimed to investigate and compare the effect of Elaeagnus angustifolia extract and quercetin on the mouse model of ...
Mitra Heydari Nasrabadi, Malahat Parsivand, Narges Mohammadi, Nastaran Asghari Moghaddam   +3 more
doaj   +1 more source

Role of Gene Polymorphisms of Matrix Metalloproteinases-2, -3 and -13 in the Development of Coronary Artery Atherosclerosis in Patients with Primary Polyosteoarthrosis

Архивъ внутренней медицины, 2020
The aim of the research. To assess the influence of polymorphisms of the matrix metalloproteinase genes — 2 (rs2285053), — 3 (rs3025058), and — 13 (rs2252070) on the development of coronary atherosclerosis in patients with primary osteoarthritis ...
O. O. Portyannikova, E. N. Romanova, A. V. Govorin, S. M. Tsvinger   +3 more
doaj   +1 more source

Matrix metalloproteinase 13, a new target for therapy in Alzheimer's disease. [PDF]

Genes Dis, 2019
Alzheimer's disease (AD), the most common neurodegenerative disorder, affects millions of people worldwide. In a recent publication, Guo-Jun Chen and colleagues highlight the role of matrix metalloproteinase (MMP) 13 (also called Collagenase 3) in AD pathogenesis through regulating BACE1, 1 a rate-limiting enzyme for β-amyloid (Aβ ...
Paumier JM, Thinakaran G.
europepmc   +3 more sources

The expression of matrix metalloproteinase-13 (MMP-13) on xenograft and PRF in bone regeneration

Brazilian Dental Science, 2023
Objective: inflammation may play a role in bone loss by altering the bone remodelling process, favouring bone resorption by osteoclasts over bone synthesis by osteoblasts.
Eka Fitria Augustina, Nur Riflianty Rivai, Haykal Miftah Gifary   +2 more
doaj   +1 more source

Matrix Metalloproteinase 13 Inhibitors for Modulation of Osteoclastogenesis: Enhancement of Solubility and Stability. [PDF]

ChemMedChem, 2021
AbstractMatrix metalloproteinase 13 (MMP‐13) activity has been correlated to breast cancer bone metastasis. It has been proposed that MMP‐13 contributes to bone metastasis through the promotion of osteoclastogenesis. To explore the mechanisms of MMP‐13 action, we previously described a highly efficacious and selective MMP‐13 inhibitor, RF036 ...
Knapinska AM, Singh C, Drotleff G, Blanco D, Chai C, Schwab J, Herd A, Fields GB.   +7 more
europepmc   +3 more sources

Characterization of an exosite binding inhibitor of matrix metalloproteinase 13 [PDF]

Protein Science, 2008
AbstractMatrix metalloproteinase 13 (MMP13) is a key enzyme implicated in the degradation of the extracellular matrix in osteoarthritis. Clinical administration of broad spectrum MMP inhibitors such as marimastat has been implicated in severe musculo‐skeletal side effects. Consequently, research has been focused on designing inhibitors that selectively
Lata T, Gooljarsingh, Ami, Lakdawala, Frank, Coppo, Lusong, Luo, Gregg B, Fields, Peter J, Tummino, Richard R, Gontarek   +6 more
openaire   +2 more sources

The association between MMP−13 rs478927 gene polymorphism and dental caries susceptibility in children with mixed dentition from Birjand, Iran: A case‐control study

Health Science Reports, 2023
Background and Aims Gene polymorphisms are responsible for at least part of the variation in caries susceptibility despite similar environmental factors.
Ebrahim Miri‐Moghaddam, Fatemeh Sadat Mousavi, Hamid Salehiniya, Farzaneh Vafaeie, Hamid Abbaszadeh   +4 more
doaj   +1 more source

Targeting matrix metalloproteinase‐13 in bronchial epithelial repair [PDF]

Clinical & Experimental Allergy, 2018
AbstractBackgroundViral infection of the bronchial epithelium disrupts the barrier properties of the epithelium in healthy individuals and those with lung disease. Repair of the bronchial epithelium is dependent of the formation of a provisional fibrin matrix and migration of epithelial cells to cover denuded areas, followed by proliferation and ...
Christopher Howell, James R. Smith, Janis K. Shute   +2 more
openaire   +2 more sources

Evaluation of the Effect of Phytocomplex on Chondroprotective Biomarkers in an Experimental Model of Osteoarthritis in Rats [PDF]

Modern Medicine, 2022
Osteoarthritis (OA) is most prevalent joint disease and major contributor to non-fatal burden in India, with prevalence rates of 22% - 39%. The use of conventional medication can be associated with insufficient clinical management and serious side ...
Shridhar PANDYA, Chetan SAVALIYA, Dheeraj NAGORE, Vaishali UNDALE, Shubhada KHADE, Nishant MANTE   +5 more
doaj   +1 more source

Matrix metalloproteinases at key junctions in the pathomechanism of stroke [PDF]

, 2011
Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Kolev, Kraszimir, Kolev Krasimir, Rottenberger Zsolt, Zsolt Rottenberger, Rottenberger, Zsolt, Krasimir Kolev   +5 more
core   +1 more source