Results 21 to 30 of about 198,679 (292)

In silico Study of Some Natural Anthraquinones on Matrix Metalloproteinase Inhibition [PDF]

Research Journal of Pharmacognosy, 2021
Background and objectives: Matrix metalloproteinase-13 (MMP-13) is a proteolytic enzyme playing an important role in the activation of the MMP cascade, which seems to be vital in both bone metabolism and homeostasis.
Amir Taherkhani, Shirin Moradkhani, Athena Orangi, Alireza Jalalvand, Zahra Khamverdi*   +4 more
doaj   +1 more source

Role of Gene Polymorphisms of Matrix Metalloproteinases-2, -3 and -13 in the Development of Coronary Artery Atherosclerosis in Patients with Primary Polyosteoarthrosis

Архивъ внутренней медицины, 2020
The aim of the research. To assess the influence of polymorphisms of the matrix metalloproteinase genes — 2 (rs2285053), — 3 (rs3025058), and — 13 (rs2252070) on the development of coronary atherosclerosis in patients with primary osteoarthritis ...
O. O. Portyannikova, E. N. Romanova, A. V. Govorin, S. M. Tsvinger   +3 more
doaj   +1 more source

The expression of matrix metalloproteinase-13 (MMP-13) on xenograft and PRF in bone regeneration

Brazilian Dental Science, 2023
Objective: inflammation may play a role in bone loss by altering the bone remodelling process, favouring bone resorption by osteoclasts over bone synthesis by osteoblasts.
Eka Fitria Augustina, Nur Riflianty Rivai, Haykal Miftah Gifary   +2 more
doaj   +1 more source

Characterization of an exosite binding inhibitor of matrix metalloproteinase 13 [PDF]

Protein Science, 2008
AbstractMatrix metalloproteinase 13 (MMP13) is a key enzyme implicated in the degradation of the extracellular matrix in osteoarthritis. Clinical administration of broad spectrum MMP inhibitors such as marimastat has been implicated in severe musculo‐skeletal side effects. Consequently, research has been focused on designing inhibitors that selectively
Lata T, Gooljarsingh, Ami, Lakdawala, Frank, Coppo, Lusong, Luo, Gregg B, Fields, Peter J, Tummino, Richard R, Gontarek   +6 more
openaire   +2 more sources

The association between MMP−13 rs478927 gene polymorphism and dental caries susceptibility in children with mixed dentition from Birjand, Iran: A case‐control study

Health Science Reports, 2023
Background and Aims Gene polymorphisms are responsible for at least part of the variation in caries susceptibility despite similar environmental factors.
Ebrahim Miri‐Moghaddam, Fatemeh Sadat Mousavi, Hamid Salehiniya, Farzaneh Vafaeie, Hamid Abbaszadeh   +4 more
doaj   +1 more source

Comparison of matrix metalloproteinase-13 and tissue inhibitor of metalloproteinase-1 levels and alveolar bone density in chronic periodontitis before and after scaling and root planning

Majalah Kedokteran Gigi Indonesia, 2022
Periodontitis is typically associated with disorders characterized by compromised tooth-supporting tissue. Damage to periodontal tissue is caused by an imbalance between matrix metalloproteinases and their inhibitors.
Aini Hariyani Nasution, Lidya Irani Nainggolan, Widianto Meydhyono   +2 more
doaj   +1 more source

Evaluation of the Effect of Phytocomplex on Chondroprotective Biomarkers in an Experimental Model of Osteoarthritis in Rats [PDF]

Modern Medicine, 2022
Osteoarthritis (OA) is most prevalent joint disease and major contributor to non-fatal burden in India, with prevalence rates of 22% - 39%. The use of conventional medication can be associated with insufficient clinical management and serious side ...
Shridhar PANDYA, Chetan SAVALIYA, Dheeraj NAGORE, Vaishali UNDALE, Shubhada KHADE, Nishant MANTE   +5 more
doaj   +1 more source

Targeting matrix metalloproteinase‐13 in bronchial epithelial repair [PDF]

Clinical & Experimental Allergy, 2018
AbstractBackgroundViral infection of the bronchial epithelium disrupts the barrier properties of the epithelium in healthy individuals and those with lung disease. Repair of the bronchial epithelium is dependent of the formation of a provisional fibrin matrix and migration of epithelial cells to cover denuded areas, followed by proliferation and ...
Christopher Howell, James R. Smith, Janis K. Shute   +2 more
openaire   +2 more sources

Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression [PDF]

, 2023
三重大学博士(医学)application/pdfIdiopathic pulmonary fibrosis is a progressive and fatal disease with a poor prognosis.Matrix metalloproteinase-2 is involved in the pathogenesis of organ fibrosis.
井上, 亮, Inoue, Ryo, イノウエ, リョウ   +2 more
core   +1 more source

Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and-13 and of TIMP-1 [PDF]

, 2000
Bachmeier BE, Nerlich AG, Boukamp P, et al. Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and-13 and of TIMP-1. BIOLOGICAL CHEMISTRY.
Boukamp, P, Tschesche, Harald, Bachmeier, BE, Bachmeier, B. E., Nerlich, A. G., Fink, E., Fritz, H, Fink, E, Fritz, H., Tschesche, H., Lichtinghagen, R., Nerlich, AG, Lichtinghagen, R, Boukamp, P.   +13 more
core   +1 more source