Results 41 to 50 of about 198,679 (292)
TIPE2 Mediates the Suppressive Effects of Shikonin on MMP13 in Osteosarcoma Cells
Cellular Physiology and Biochemistry, 2015 Background/Aims: Osteosarcoma (OS) is a primary malignant bone tumor in humans, and is notorious mainly for its distal metastases. We have recently shown that Shikonin, an effective constituent extracted from Chinese medicinal herb, inhibits OS cell ...
Biyong Deng, Youwei Feng, Bixiang Deng
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Matrix metalloproteinase-13 expression in the progression of colorectal adenoma to carcinoma
Tumor Biology, 2014 Most colorectal carcinomas (CRCs) are considered to arise from conventional adenoma based on the concept of the adenoma-carcinoma sequence. Matrix metalloproteinases (MMPs) are known to be overexpressed as normal mucosa progresses to adenomas and carcinomas.
Abd Al-Rahman Mohammad, Foda +2 more
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BMC Cancer, 2008 Background Experimental evidence suggests that matrix metalloproteinase-13 (MMP-13) protein may promote breast tumor progression, however, its role is yet to be fully established.
Ning Liansheng +12 more
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Life, 2022 Osteoarthritis (OA) is the most common degenerative joint disease characterized by enzymatic degradation of the cartilage extracellular matrix (ECM) causing joint pain and disability.
Omer S. Ashruf, Mohammad Yunus Ansari
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Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds [PDF]
Bioorganic & Medicinal Chemistry Letters, 2011 Matrix metalloproteinase-13 (MMP-13) has been implicated as the protease responsible for collagen degradation in cartilage during osteoarthritis (OA). Compounds that inhibit the metalloproteinase at the Zn binding site typically lack specificity among MMP family members.
Joshua, Roth +7 more
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Development of a Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-7/-13 Inhibitor
Molecules, 2017 Matrix metalloproteinase 7 (MMP-7) is a member of the MMP superfamily and is able to degrade extracellular matrix proteins such as casein, gelatin, fibronectin and proteoglycan.
Thomas Fischer, Rainer Riedl
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Matrix metalloproteinases at key junctions in the pathomechanism of stroke
, 2011 Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Kolev, Kraszimir +5 more
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Shiyan dongwu yu bijiao yixue, 2023 ObjectiveTo study the effect of Xiaoyusan new formula on the articular cartilage of knee osteoarthritis (KOA) rabbits and its mechanism.MethodsA total of 42 New Zealand white rabbits aged 6 months were randomly divided into normal group, model group ...
CUI Ruolin +9 more
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Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells [PDF]
, 2007 MMP-9 (matrix metalloproteinase 9) plays a critical role in tumour progression. Although the biochemical properties of the secreted form of proMMP-9 are well characterized, little is known about the function and activity of cell surface-associated proMMP-
Mentele, Reinhard +6 more
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The effect of Satureja sahendica Bornm essential oil on the expression of metalloproteases1, 2, 9 and 13 in bovine fibroblast - like syniviocytes [PDF]
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2023 Introduction: Osteoarthritis is a progressive, age-related disease characterized by cartilage destruction, subchondral bone formation, and inflammation of the synovial membrane.
Hossein Maghsoudi +2 more
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