Results 111 to 120 of about 19,663,610 (303)

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Cell-based gene therapy modifies matrix remodeling after a myocardial infarction in tissue inhibitor of matrix metalloproteinase-3–deficient mice [PDF]

, 2009
ObjectiveCell-based gene therapy can enhance the effects of cell transplantation by temporally and spatially regulating the release of the gene product. The purpose of this study was to evaluate transient matrix metalloproteinase inhibition by implanting
Seneviratne, Charit K., Fedak, Paul W., Li, Ren-Ke, Lai, Teresa Y.Y., Degousee, Norbert, Weisel, Richard D., Rafati, Shahin, Angoulvant, Denis, Fazel, Shafie, Chen, Liwen   +9 more
core   +1 more source

Temporal Patterns of 14 Blood Biomarker candidates of Cardiac Remodeling in Relation to Prognosis of Patients With Chronic Heart Failure—The Bio‐SHiFT Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Remodeling biomarkers carry high potential for predicting adverse events in chronic heart failure (CHF) patients. However, temporal patterns during the course of CHF, and especially the trajectory before an adverse event, are unknown.
Elke Bouwens, Milos Brankovic, Henk Mouthaan, Sara Baart, Dimitris Rizopoulos, Nick van Boven, Kadir Caliskan, Olivier Manintveld, Tjeerd Germans, Jan van Ramshorst, Victor Umans, K. Martijn Akkerhuis, Isabella Kardys   +12 more
doaj   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Functional studies of matrix metalloproteinases (MMP14, 15, 16) in animal and cell culture models [PDF]

, 2003
Li H. Functional studies of matrix metalloproteinases (MMP14, 15, 16) in animal and cell culture models. Bielefeld (Germany): Bielefeld University; 2003.It has been known, MT1-, 2-, 3-, 5-MMP have a transmembrane (TM) domain and MT4-, 6-MMP contain a GPI
Li, Hongbin
core  

Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression [PDF]

, 2008
Matrix metalloproteinase (MMP) 13 (collagenase 3) is an extracellular matrix remodeling enzyme that is induced in myofibroblasts during the earliest invasive stages of human breast carcinoma, suggesting that it is involved in tumor progression.
Lund, Leif R, Zena Werb, Dylan R Edwards, Askautrud, Hanne A, Lund, Leif R., Mikala Egeblad, Pedersen, T. X., Edwards, D. R., Leif R Lund, Rank, Fritz, Ib J Christensen, Pedersen, Tanja X., Fritz Rank, Nielsen, Boye S., Christensen, Ib J, Askautrud, Hanne A., Lund, L. R., Edwards, Dylan R., Tanja X Pedersen, Boye S Nielsen, Werb, Zena, Egeblad, M., Christensen, I. J., Caroline J Pennington, Hanne A Askautrud, Rank, F., Edwards, Dylan R, Werb, Z., Askautrud, H. A., Nielsen, Boye S, Pennington, C. J., Egeblad, Mikala, Christensen, Ib J., Pennington, Caroline J, Pennington, Caroline J., Nielsen, B. S., Pedersen, Tanja X   +36 more
core   +1 more source

Matrix metalloproteinase 2, 3, and 9 gene polymorphisms in women with rheumatoid arthritis

Терапевтический архив, 2015
Aim. To study the promoter regions of the matrix metalloproteinase (MMP)2, MMP3, and MMP9 genes to assess their associations with the risk of rheumatoid arthritis (RA) and with the types of its clinical course in women. Subjects and methods.
A V Shevchenko, V I Konenkov, M A Korolev, Yu B Ubshaeva, V F Prokofiev   +4 more
doaj  

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source