Results 221 to 230 of about 386,755 (358)

Matrix Metalloproteinase-9 as a Novel Player in Synaptic Plasticity and Schizophrenia.

Schizophrenia bulletin, 2015
Katarzyna Lepeta, L. Kaczmarek
semanticscholar   +1 more source

Stepwise Regulation of Cellular Oxidative Stress via Conductive‐Piezoelectric Integrated Microstructured Conduits for Enhanced Nerve Regeneration

Advanced Science, EarlyView.
This study presents a conductive‐piezoelectric integrated microstructured conduit for peripheral nerve regeneration. The conduit combines reduced graphene oxide with a piezoelectric nanofiber membrane, enhancing nerve repair through physical guidance, oxidative stress inhibition, and ultrasound‐activated electrical stimulation.
Dong Zhou, Mengxuan Bian, Lingyu Wei, Binghuang Yao, Qi Chen, Lan Xiao, Jing He, Jian Zhang, Yulin Li, Libo Jiang   +9 more
wiley   +1 more source

Matrix Metalloproteinase-9 (MMP-9) as a Therapeutic Target: Insights into Molecular Pathways and Clinical Applications. [PDF]

Pharmaceutics
Wolosowicz M, Prokopiuk S, Kaminski TW.
europepmc   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Serum matrix metalloproteinase-9 levels and enzymatic activity in patients with anti-glomerular basement membrane disease. [PDF]

Front Med (Lausanne)
Kuang H, Wan HS, Gu QH, Jia XY, Cui Z, Zhao MH.   +5 more
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Streptococcus pneumoniae infection is associated with matrix metalloproteinase-9 in lung cancer progression and brain metastases. [PDF]

Sci Rep
Gao L, Dhilipkannah P, Jiang F.
europepmc   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

High intra-tumoral and serum matrix metalloproteinase 9 levels are associated with reduced survival of patients with glioblastoma and brain metastases. [PDF]

Front Oncol
Kaisman-Elbaz T, Haddad-Shlaifshtein S, Eskira Y, Merkin V, Dumanis G, Turiel S, Atar-Vardi M, Bari R, Alt A, Zamed T, Rotem-Dai N, Lavrenkov K, Kezerle Y, Dyomin V, Razon R, Chakraborty M, Asraf H, Hershfinkel M, Melamed I.   +18 more
europepmc   +1 more source