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Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview.
European journal of medicinal chemistry, 2020Matrix metalloproteinases (MMPs) are zinc dependent proteolytic metalloenzyme. MMP-9 is one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to degrade the extracellular matrix (ECM) components and has important role in the ...
S. Mondal +4 more
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Role of Matrix Metalloproteinase 9 in Ocular Surface Disorders.
Eye & contact lens, 2020OBJECTIVES (1) To explore the role and significance of Matrix Metalloproteinase 9 (MMP-9), a proteolytic enzyme, in various ocular surface diseases of inflammatory, infectious, and traumatic etiology (2), to further elucidate the molecular mechanisms ...
Emery C. Jamerson +4 more
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Matrix Metalloproteinase-9 in Cerebral Aneurysms
Neurosurgery, 1997Generalized disruption of arterial wall morphological changes in patients harboring cerebral aneurysms has been documented; however, little is known regarding the pathogenesis of these changes. To explore the role of the elastolytic gelatinase, matrix metalloproteinase-9 (MMP-9), levels of this enzyme in the wall of intracranial aneurysms were compared
S C, Kim +6 more
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Matrix Metalloproteinase-9 in Lung Remodeling
American Journal of Respiratory Cell and Molecular Biology, 2003Matrix metalloproteinase (MMP)-9 (Gelatinase B, 92-kD type IV collagenase, EC 3.4.24.35) is an MMP that is present in low quantities in the healthy adult lung, but much more abundant in several lung diseases, including asthma, idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD).
Jeffrey J, Atkinson, Robert M, Senior
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Matrix Metalloproteinase-9 and Autoimmune Diseases
Journal of Clinical Immunology, 2006Matrix metalloproteinases (also named matrixin or MMPs) are a major group of enzymes that regulate cell-matrix composition by using zinc for their proteolytic activities. They are essential for various normal biological processes such as embryonic development, morphogenesis, reproduction tissue resorption, and remodeling. Metalloproteinases also play a
Maya, Ram +2 more
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Exhaled Matrix Metalloproteinase-9 in Lung Cancer
Rejuvenation Research, 2012Background: Matrix metalloproteinase-9 (MMP-9) has been recognized in several types of tumor development and progression, including lung cancer, for its role in the degradation and remodeling of lung tissue. Furthermore, increased MMP-9 has been commonly described in the serum and airways of non-small cell lung ...
CARPAGNANO, GIOVANNA ELISIANA +5 more
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RECK Negatively Regulates Matrix Metalloproteinase-9 Transcription
Cancer Research, 2009Abstract RECK, a glycosylphosphatidylinositol-anchored glycoprotein, inhibits the enzymatic activities of some matrix metalloproteinases (MMP), thereby suppressing tumor cell metastasis; however, the detailed mechanism is still obscure.
Satoshi, Takagi +2 more
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“Uncorking” of liposomes by matrix metalloproteinase-9
Chem. Commun., 2005A triggered release methodology of liposomal contents via the enzyme MMP-9 is described.
Nihar R, Sarkar +6 more
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Matrix Metalloproteinase-9 in Peripheral Blood Eosinophils
International Archives of Allergy and Immunology, 1999<i>Background:</i> Matrix metalloproteinases (MMPs) are major contributors to tumor invasion, remodeling of connective tissue and infiltration of inflammatory cells and may be important mediators in developing allergic inflammation. Overexpression of MMP-9 mRNA by eosinophils in the asthmatic airways has been reported.
T, Fujisawa +4 more
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