Results 181 to 190 of about 2,335,867 (359)

Matrix metalloproteinase interactions with collagen and elastin

Matrix Biology, 2015
S. V. Van Doren
semanticscholar   +1 more source

Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases.

, 1990
Christopher M. Overall, Jaro Sodek
openalex   +1 more source

Inhibition of the matrix metalloproteinase system in a rat model of chronic cyclosporine nephropathy [PDF]

, 1998
Carla Duymelinck, Jingti Deng, Simonne E.H. Dauwe, Marc E. De Broe, Gert A. Verpooten   +4 more
openalex   +1 more source

DNA Origami‐Based CD44‐Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression

Advanced Science, EarlyView.
This study develops a cartilage‐targeted DNA origami system (OCS) that protects and delivers si‐Stat3 to chondrocytes. OCS reduces MMP13 expression, enhances extracellular matrix stability, and lowers oxidative stress while improving cell survival. In vivo, OCS decreases cartilage degradation biomarkers and promotes tissue repair factors, demonstrating
Qi Lv, Xiang Zhao, Songsong Teng, Xinmeng Jin, Ying Zhou, Yueyang Sun, Hao Pei, Zuoqin Yan, Chunhui Ma   +8 more
wiley   +1 more source

Is there new hope for therapeutic matrix metalloproteinase inhibition?

Nature reviews. Drug discovery, 2014
R. Vandenbroucke, C. Libert
semanticscholar   +1 more source

Membrane-type matrix metalloproteinase-1(MT1-MMP) gene is overexpressed in highly invasive hepatocellular carcinomas [PDF]

, 1998
T. HARADA, Shigeki Arii, Masahiro Mise, Takashi Imamura, Hiroaki Higashitsuji, Masaharu Furutani, Mototaka Niwano, Shunichi Ishigami, Manabu Fukumoto, Motoharu Seiki, Hiroshi Sato, Masayuki Imamura   +11 more
openalex   +1 more source

An Off‐the‐Shelf Artificial Blood Clot Hydrogel Neutralizing Multiple Proinflammatory Mediators for Pro‐Regenerative Periodontitis Treatment

Advanced Science, EarlyView.
CCS‐RSF@PRP hydrogel is engineered to structurally and functionally mimic the blood clot by integrating PPR, CCS, and RSF nanofibers through in situ activation of PRP. In a rat periodontitis model, CCS‐RSF@PRP hydrogel effectively promotes periodontal tissue repair, attributing to neutralizing the multiple proinflammatory mediators, thus rebuilding a ...
Yini Huangfu, Zhezhe Zhao, Xiang Liu, Jingrong Wang, Yufeng Zhang, Tingting Lan, Yonglan Wang, Chenxuan Wu, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Anjie Dong, Zujian Feng, Deling Kong, Weiwei Wang   +14 more
wiley   +1 more source

Antidiabetic effect of KB–R7785, a novel matrix metalloproteinase inhibitor, in KK-Ay mice

, 1998
Noriyasu Nishimura, Kaori Nishikawa, Kei Naruse, Koji Yamamoto, Kiyoshi Yoshino   +4 more
openalex   +1 more source

Delayed Transplantation of Neural Stem Cells Improves Initial Graft Survival after Stroke

Advanced Science, EarlyView.
Delayed transplantation of human iPSC‐derived neural progenitor cells (NPCs) enhances graft survival, proliferation, and axonal sprouting after stroke. Using bioluminescence imaging and histology in a mouse model of stroke, it is shown that NPC delivery at 7 days post‐stroke is more effective than acute transplantation, highlighting the importance of ...
Rebecca Z Weber, Nora H Rentsch, Beatriz Achón Buil, Melanie Generali, Lina R. Nih, Christian Tackenberg, Ruslan Rust   +6 more
wiley   +1 more source