Results 181 to 190 of about 2,315,187 (340)

Synovial Fluid‐derived Micrococcus Luteus G18 Exacerbates Osteoarthritis Progression by Promoting Chondrocyte Degradation via TLR2/JNK/AP‐1 Signaling Pathway

Advanced Science, EarlyView.
Traditionally considered sterile, the articular cavity is now recognized to harbor microbial communities influencing osteoarthritis (OA). Integrating 16S rRNA sequencing and culturomics, Micrococcus luteus is enriched in advanced OA. Notably, M. luteus G18 exacerbates cartilage degeneration via TLR2/JNK/AP‐1‐mediated ECM disruption, revealing intra ...
Tingtao Chen, Qingwei Zeng, Tangchang Xu, Xinyue Qi, Kaiyi Li, Jing Wei, Liang Hao   +6 more
wiley   +1 more source

Extracellular matrix metalloproteinase inducer shows active perivascular cuffs in multiple sclerosis.

Brain : a journal of neurology, 2013
Smriti M. Agrawal, J. Williamson, Ritu Sharma, Hania Kebir, K. Patel, A. Prat, V. Yong   +6 more
semanticscholar   +1 more source

Doxycycline inhibits matrix metalloproteinase-9 and laminin degradation after transient global cerebral ischemia

, 2009
Hyung Lee, Jong‐Wook Park, Sang-Pyo Kim, Eng H. Lo, Seong‐Ryong Lee   +4 more
openalex   +2 more sources

Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early‐Onset Colorectal Cancer

Advanced Science, EarlyView.
This study identifies a unique physical signature of colorectal cancer in younger adults: their tissues are mechanically stiffer than those in older patients with the same cancer. Furthermore, stromal remodeling in early‐onset colorectal cancer promotes epithelial mechanotransduction and proliferation, showing how mechanical alterations in the tissue ...
Nicole C. Huning, Munir H. Buhaya, Victor V. Nguyen, Afeefah Khazi‐Syed, Haider A. Ali, Adil Khan, Angela Fan, Robert C. Fisher, Zhikai Chi, Indu Raman, Guangchun Chen, Chengsong Zhu, Mengxi Yu, Andrew R. Jamieson, Sara Roccabianca, Victor D. Varner, Cheryl M. Lewis, Emina H. Huang, Jacopo Ferruzzi   +18 more
wiley   +1 more source

Genistein Inhibits Fine-Dust-Induced Matrix Metalloproteinase-1 in Human Keratinocytes. [PDF]

Pharmaceuticals (Basel)
Song DK, Jeong YY, Roh E, Shin HY, Kim JE.   +4 more
europepmc   +1 more source

Perioceutics: Matrix metalloproteinase inhibitors as an adjunctive therapy for inflammatory periodontal disease

, 2012
EstherNalini Honibald, Sebeena Mathew, Jeyantha Padmanaban, Elanchezhiyan Sundaram, RenukaDevi Ramamoorthy   +4 more
openalex   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Matrix Metalloproteinase-Mediated Disruption of Tight Junction Proteins in Cerebral Vessels is Reversed by Synthetic Matrix Metalloproteinase Inhibitor in Focal Ischemia in Rat

Journal of Cerebral Blood Flow and Metabolism, 2007
Yi Yang, Eduardo Y. Estrada, Jeffrey F. Thompson, Wenlan Liu, G. Rosenberg   +4 more
semanticscholar   +1 more source

Protease‐Activated Plasmonic Nanosensors for Predictive Ultrasound‐Guided Photoacoustic Imaging of Tumor Responses to Adoptive T Cell Therapy

Advanced Science, EarlyView.
Protease‐activated plasmonic nanosensors are demonstrated to noninvasively monitor antitumor T cell activity in tumors with anatomical information upon adoptive T cell transfer via ultrasound‐guided photoacoustic imaging. These nanosensors are actuated by granzyme B, a protease secreted by activated cytotoxic T cells during tumor cell killing, which ...
Myeongsoo Kim, Seoyoon Song, Ali Zamat, Paul S. Pelkowski, Shivashankar Subramanian, Melissa Cadena, Sydney Fabrega, Meredith Brienen, Jinhwan Kim, Gabriel A. Kwong, Stanislav Y. Emelianov   +10 more
wiley   +1 more source

Effects of matrix metalloproteinase inhibition in cultured human Tenon's capsule fibroblasts. [PDF]

BMC Ophthalmol
Kim NH, Han KE, Jun RM, Sohn S, Kee C, Suh W.   +5 more
europepmc   +1 more source