Results 251 to 260 of about 2,395,043 (357)

MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators

Molecular and Cellular Biology, 2008
Galina Gabriely, T. Wurdinger, S. Kesari, Christine Esau, J. Burchard, P. Linsley, Anna M. Krichevsky   +6 more
semanticscholar   +1 more source

KLK1 as an Epithelial‐Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R‐Mediated Fibroblast Phenotypic Transition

Advanced Science, EarlyView.
KLK1 downregulation disrupts the intestinal mucosal barrier and impairs kallikrein‐kinin signaling, thereby reducing Lys‐des‐Arg9‐BK production. This enhances B1R activation on ADAMDEC1⁺ fibroblasts, promoting inflammation and extracellular matrix (ECM) remodeling. The resulting iCAFs promote colorectal cancer progression, highlighting a novel KLK1‐B1R
Lisha Zhou, Meijing Wang, Shunji Liu, Limei Gu, Shijia Liu, Qianming Du, Tianyi Zhang, Yinuo Ma, Lixin Zhao, Jiaming Wang, Qiang Xu, Tingsheng Ling, Haibo Cheng, Hongqi Chen, Yang Sun   +14 more
wiley   +1 more source

Bioresponsive Hyaluronic Acid-Based Hydrogel Inhibits Matrix Metalloproteinase-2 in Glioblastoma Microenvironment. [PDF]

ChemMedChem
Barbugian F, Salerno D, Ballarini E, Crippa L, Francesconi O, Mantegazza F, Cavaletti G, Roelens S, Leone G, Pepi S, Talarico L, Magnani A, Nativi C, Russo L.   +13 more
europepmc   +1 more source

Matrix metalloproteinases and TIMPS in cultured C57BL/6J-cpk kidney tubules

, 1996
Carolyn A. Rankin, Ko Suzuki, Yoshifumi Itoh, Donna Ziemer, Jared J. Grantham, James P. Calvet, Hideaki Nagase   +6 more
openalex   +1 more source

Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-β1 release [PDF]

, 1997
Kazushi Imai, Ari HIRAMATSU, Daikichi Fukushima, Michael D. Pierschbacher, Yasunori Okada   +4 more
openalex   +1 more source

Nociceptive Nerve‐Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140b+ CD146+ Fibroblast Differentiation

Advanced Science, EarlyView.
This study investigates adenomyosis fibrosis in relation to nociceptive nerves. Nociceptive nerve‐secreted CGRP promotes RAMP1hi CD140b+ CD146+ fibroblast differentiation into myofibroblasts through ERK activation, causing severe fibrosis. Rimegepant‐induced CGRP/RAMP1 signaling blockade alleviates fibrosis and restores fertility in a mouse model. This
Zi Ye, Anning Zhao, Xia Li, Yanqing Hao, Dong Huang, Jianmin Chen, Tiantian Li, Yangyang Dai, Wenchao Sun, Lie Ma, Songying Zhang, Liaobing Xin   +11 more
wiley   +1 more source

Association of Matrix Metalloproteinase-2 Promoter Genotypes With Leiomyoma Risk. [PDF]

Cancer Genomics Proteomics
Chang SY, Chang WS, Tsai CW, Wang YC, Shih HY, Su CH, Bau DT.   +6 more
europepmc   +1 more source

Subtractive Cloning Identifies Tissue Inhibitor of Matrix Metalloproteinase-1 (TIMP-1) Increased Gene Expression Following Focal Stroke [PDF]

, 1998
Xinkang Wang, Frank C. Barone, Raymond F. White, Giora Feuerstein   +3 more
openalex   +1 more source

Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood–Brain Barrier and White Matter Components after Cerebral Ischemia

Journal of Neuroscience, 2001
M. Asahi, Xiaoying Wang, Tatsuro Mori, T. Sumii, Jae‐Chang Jung, M. A. Moskowitz, M. E. Fini, E. Lo   +7 more
semanticscholar   +1 more source

Cerebral Organoids with Integrated Endothelial Networks Emulate the Neurovascular Unit and Mitigate Core Necrosis

Advanced Science, EarlyView.
Fumadó Navarro et al. present an optimized strategy to generate vascular‐like networks that infiltrate within cerebral organoids with promising signs of blood‐brain barrier characteristics, preserved stiffness, uniform morphology, enhanced media diffusion, and reduced necrotic core.
Josep Fumadó Navarro, Siobhan Crilly, Wai Kit Chan, Shane Browne, John O. Mason, Catalina Vallejo‐Giraldo, Abhay Pandit, Mihai Lomora   +7 more
wiley   +1 more source