Results 231 to 240 of about 162,031 (260)
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Matrix Metalloproteinases in Atherothrombosis
Progress in Cardiovascular Diseases, 2010The metalloproteinases (MMPs, matrixins) are zinc-containing endopeptidases involved in the metabolism of extracellular matrix as well as in the cleavage of other proteins. The MMP family currently consists of 28 enzymes with somewhat different activities.
Magnus, Bäck +2 more
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Matrix Metalloproteinases and the Thyroid
Thyroid, 2000Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade components of the extracellular matrix (ECM) and basement membrane. They play a critical role in many physiological and pathological processes, such as tumor metastasis. The original concept-that MMP activity during metastasis is restricted solely to invasion of the basement membrane
Z, Kraiem, S, Korem
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Matrix Metalloproteinases and Endometriosis
Seminars in Reproductive Medicine, 2003Retrograde menstruation represents a plausible explanation for the development of most cases of endometriosis; nevertheless, additional factors must contribute to the development of disease in only 10 to 20% of women. The discriminating factor(s) in determining the development of active endometriosis probably involves a complex array of potentially ...
Kevin G, Osteen +2 more
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Matrix metalloproteinases and angiogenesis
Current Opinion in Nephrology and Hypertension, 2002Angiogenesis is a prominent feature of numerous diseases, including cancer and arthritis, and appears to play an important role in kidney disease and hypertension. The matrix metalloproteinases, especially matrix metalloproteinase-2, play a vital role during angiogenesis by degrading the surrounding extracellular matrix and allowing endothelial cell ...
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Matrix metalloproteinases at a glance
Journal of Cell ScienceABSTRACT Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that belong to the group of endopeptidases or matrixins. They are able to cleave a plethora of substrates, including components of the extracellular matrix and cell-surface-associated proteins, as well as intracellular targets. Accordingly, MMPs play key
Sven Hey, Stefan Linder
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Multifunctional intracellular matrix metalloproteinases: implications in disease
FEBS Journal, 2021Wesam Bassiouni +2 more
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The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases
International Journal of Molecular Sciences, 2020Claudia Castruita-De la Rosa +2 more
exaly