Results 231 to 240 of about 155,893 (261)

Matrix metalloproteinases at a glance

Journal of Cell Science
ABSTRACT Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that belong to the group of endopeptidases or matrixins. They are able to cleave a plethora of substrates, including components of the extracellular matrix and cell-surface-associated proteins, as well as intracellular targets. Accordingly, MMPs play key
Sven Hey, Stefan Linder
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Matrix metalloproteinases and bone

Bone, 2008
Matrix metalloproteinases (MMPs) are members of a family of zinc-dependent proteolytic enzymes. Several of the MMPs are expressed at high levels in bone and cartilage in mammals including humans and mice and are capable of cleaving native, undenatured collagens with long uninterrupted triple helices; these MMPs therefore potentially function as ...
Stephen M, Krane, Masaki, Inada
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Matrix metalloproteinases in inflammation

Biochimica et Biophysica Acta (BBA) - General Subjects, 2014
Matrix metalloproteinases (MMPs) are a family of ubiquitously expressed zinc-dependent endopeptidases with broad substrate specificity and strictly regulated tissue specific expression. They are expressed in physiological situations and pathological conditions involving inflammation.
Liisa, Nissinen, Veli-Matti, Kähäri
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Matrix Metalloproteinases and Their Inhibitors

2001
Matrix metalloproteinases (MMPs) are a group of 16 enzymes that are capable of degrading extracellular matrix components. Their catalytic function is dependent on a zinc ion in the active center. MMPs are separated in three groups: gelatinases (type IV-collagenases), stromelysins, and interstitial collagenases.
A, Kugler, P, Thelen, R H, Ringert
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Matrix metalloproteinase inhibitors

Current Oncology Reports, 2004
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are associated with the tumorigenic process. MMPs degrade the extracellular matrix, promoting tumor invasion and metastasis. They also regulate host defense mechanisms and normal cell function; blocking all MMPs may not lead to a positive therapeutic outcome. Most clinical
Nithya, Ramnath, Patrick J, Creaven
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Matrix metalloproteinases and angiogenesis

Current Opinion in Nephrology and Hypertension, 2002
Angiogenesis is a prominent feature of numerous diseases, including cancer and arthritis, and appears to play an important role in kidney disease and hypertension. The matrix metalloproteinases, especially matrix metalloproteinase-2, play a vital role during angiogenesis by degrading the surrounding extracellular matrix and allowing endothelial cell ...
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The matrix‐degrading metalloproteinases

BioEssays, 1992
AbstractThe matrix‐degrading metalloproteinases are an intriguing family of enzymes that have evolved to digest specific extracellular matrix components. The expression of these enzymes is very highly regulated and can be controlled transcriptionally by a number of growth factors, tumor promoters, oncogenes, and hormones.
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Matrix Metalloproteinases

Advances in Dental Research, 1995
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Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium

Fertility and Sterility, 2002
Hye Won Chung, Ji Young Lee, Hye-Sung Moon   +2 more
exaly  

The Impact of Differential Expression of Extracellular Matrix Metalloproteinase Inducer, Matrix Metalloproteinase-2, Tissue Inhibitor of Matrix Metalloproteinase-2 and PDGF-AA on the Chronicity of Venous Leg Ulcers

European Journal of Vascular and Endovascular Surgery, 2006
B Mahendran, Niamh Hynes, G Avalos
exaly