Results 291 to 300 of about 2,315,187 (340)
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Matrix metalloproteinase inhibitors
Breast Cancer Research and Treatment, 1997Matrix metalloproteinases (MMPs) are a family of enzymes responsible for the breakdown of proteins of connective tissue. Through this action they play an important role in growth, development and tissue repair. Recent studies also suggest that MMPs are utilised in cancer, facilitating both local tumour invasion and metastasis.
S M, Wojtowicz-Praga +2 more
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Current Opinion in Chemical Biology, 1998
Matrix metalloproteinases are a family of highly regulated peptidases that are collectively responsible for the degradation of extracellular matrix during tissue remodeling. Dysregulated activity has long been implicated in the pathologies of cancer and arthritis, and the number of diseases more recently associated with these enzymes has been ...
L L, Johnson, R, Dyer, D J, Hupe
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Matrix metalloproteinases are a family of highly regulated peptidases that are collectively responsible for the degradation of extracellular matrix during tissue remodeling. Dysregulated activity has long been implicated in the pathologies of cancer and arthritis, and the number of diseases more recently associated with these enzymes has been ...
L L, Johnson, R, Dyer, D J, Hupe
openaire +2 more sources
Matrix degrading metalloproteinases
Journal of Neuro-Oncology, 1994Matrix degrading metalloproteinases are enzymes that degrade proteins in tissue extracellular matrices. These proteinases exhibit specific, well defined properties that allow them to be classified into a family of enzymes. They are secreted by various cell types as the cells effect their surrounding extracellular matrix.
B W, Ennis, L M, Matrisian
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Matrix metalloproteinase inhibitors
Current Oncology Reports, 2004Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are associated with the tumorigenic process. MMPs degrade the extracellular matrix, promoting tumor invasion and metastasis. They also regulate host defense mechanisms and normal cell function; blocking all MMPs may not lead to a positive therapeutic outcome. Most clinical
Nithya, Ramnath, Patrick J, Creaven
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Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer
Seminars in Oncology, 2002Preclinical studies have provided evidence that matrix metalloproteinases (MMPs), a family of zinc-containing proteolytic enzymes, facilitate tumor invasion, the establishment of metastases, and the promotion of tumor-related angiogenesis. Matrix metalloproteinase inhibitors (MMPIs) have been shown to inhibit tumor growth and dissemination in ...
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Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview.
European journal of medicinal chemistry, 2020S. Mondal +4 more
semanticscholar +1 more source
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
Science, 2002L. Coussens, B. Fingleton, L. Matrisian
semanticscholar +1 more source
A matrix metalloproteinase expressed on the surface of invasive tumour cells
Nature, 1994Hiroshi Sato +6 more
semanticscholar +1 more source
The biofilm matrix: multitasking in a shared space
Nature Reviews Microbiology, 2022Hans-Curt Flemming +2 more
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