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Matrix Metalloproteinase 10 Contributes to Choroidal Neovascularisation
Age-related macular degeneration (AMD) is currently the main cause of severe visual loss among older adults in developed countries. The pathophysiology has not been clarified, but oxidative stress is believed to play a major role.
Jorge González-Zamora+10 more
doaj +1 more source
3D CA model of tumor-induced angiogenesis [PDF]
Tumor-induced angiogenesis is the formation of new sprouts from preexisting nearby parent blood vessels. Computationally, tumor-induced angiogenesis can be modeled using cellular automata (CA), partial differential equations, etc. In this present study, a realistic physiological approach has been made to model the process of angiogenesis by using 3D CA
arxiv
Mechanical Properties of Growing Melanocytic Nevi and the Progression to Melanoma [PDF]
Melanocytic nevi are benign proliferations that sometimes turn into malignant melanoma in a way that is still unclear from the biochemical and genetic point of view. Diagnostic and prognostic tools are then mostly based on dermoscopic examination and morphological analysis of histological tissues.
arxiv +1 more source
Matrix metalloproteinases and atherosclerosis
Matrix metalloproteinases (MMPs), a family of proteolytic enzymes that degrade extracellular matrix (ECM), seem to have an important role in pathogenesis of atherosclerosis. Released by inflammatory cells and smooth muscle cells, MMPs regulate the vascular remodeling process.
Piotr Fic+3 more
openaire +3 more sources
Matrix metalloproteinases in emphysema [PDF]
Several studies have implicated a causative role for specific matrix metalloproteinases (MMPs) in the development and progression of cigarette smoke-induced chronic obstructive pulmonary disease (COPD) and its severe sequela, emphysema. However, the precise function of any given MMP in emphysema remains an unanswered question.
Anne M. Manicone+2 more
openaire +2 more sources
Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim+3 more
wiley +1 more source
Inflammatory perivascular cuffs are comprised of leucocytes that accumulate in the perivascular space around post-capillary venules before their infiltration into the parenchyma of the central nervous system.
Smriti M. Agrawal+6 more
semanticscholar +1 more source
Matrix Metalloproteinase-1 and Matrix Metalloproteinase-9 in the Aqueous Humor of Diabetic Macular Edema Patients. [PDF]
To assess the concentrations of matrix metalloproteinase (MMP)-1 and MMP-9 in the aqueous humor of diabetic macular edema (DME) patients.The concentrations of MMP-1 and MMP-9 in the aqueous humors of 15 cataract patients and 25 DME patients were compared.
Jin-Woo Kwon, Jin A Choi, Donghyun Jee
doaj +1 more source
By fabricating and covalently assembling gelatin methacryloyl (GelMA) porous microgels, a new class of granular hydrogel scaffolds with hierarchical porosity is developed. These scaffolds have a significantly higher void fraction than their counterparts made up of nonporous microgels, enhancing cell recruitment and tissue integration. This research may
Alexander Kedzierski+9 more
wiley +1 more source
Background: Breast cancer is one of the most common cancers in the world, particularly in Iran. There are many genomic and molecular factors that cause the occurrence of breast cancer. Many markers are associated with tumor invasiveness.
Farshad Naghshvar+3 more
doaj