Results 101 to 110 of about 75,485,891 (288)

Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort [PDF]

, 2017
Background Extracellular matrix degrading proteases and their regulators play an important role in atherogenesis and subsequent plaque rupture leading to acute cardiovascular manifestations.
Mikko T Nieminen, Timo Sorsa, Kormi, Immi, Tanja Zeller, Pirkko J Pussinen, Pussinen, Pirkko J., Taina Tervahartiala, Tervahartiala, Taina, Veikko Salomaa, Zeller, Tanja, Aki S Havulinna, Sorsa, Timo, Nieminen, Mikko T., Havulinna, Aki S., Blankenberg, Stefan, Immi Kormi, Salomaa, Veikko, Stefan Blankenberg   +17 more
core   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Increased matrix-metalloproteinase-2 and matrix-metalloproteinase-9 expression in the brain of dystrophic mice

, 2006
—Brain edema and severe alterations of the glial and endothelial cells have recently been demonstrated in the dystrophin-deficient mdx mouse, an experimental model of Duchenne muscular dystrophy, and an increase in microvessel density in patients ...
Vacca, A., Corsi, P., RIBATTI, Domenico, RONCALI L., MANGIERI, DOMENICA, MANGIERI D., Ria, R., VACCA, Angelo, Crivellato, E., RIA, ROBERTO, Ribatti, D., NICO, Beatrice, ROCCARO A. M., Roccaro, A. M., Roncali, L., CRIVELLATO E., Nico, B, CORSI, Patrizia   +17 more
core   +1 more source

Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression

, 2023
Idiopathic pulmonary fibrosis is a progressive and fatal disease with a poor prognosis. Matrix metalloproteinase-2 is involved in the pathogenesis of organ fibrosis. The role of matrix metalloproteinase-2 in lung fibrosis is unclear. This study evaluated
Atsuro Takeshita, Tetsu Kobayashi, Ryo Inoue, Atsushi Tomaru, Kota Nishihama, Tatsuki Tsuruga, Toshiyuki Ito, Corina N. D’Alessandro-Gabazza, Tomohito Okano, Hajime Fujimoto, Taro Yasuma, Esteban C. Gabazza, Valeria Fridman D’Alessandro, Masaaki Toda   +13 more
core   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Inhibition of Trophoblast-Induced Spiral Artery Remodeling Reduces Placental Perfusion in Rat Pregnancy. [PDF]

, 2010
Rats harboring the human angiotensinogen and human renin genes develop preeclamptic features in pregnancy. The preeclamptic rats exhibit a deeper trophoblast invasion associated with a reduced resistance index by uterine Doppler.
Muller, DN, Cartwright, JE, Pijnenborg, R, Pijnenborg, R., Stefan Verlohren, Luft, F.C., Mueller, D.N., Lydia Hering, Morton, J., Davidge, ST, Dechend, R, Geusens, N, Robert Pijnenborg, Herse, F, Judith E. Cartwright, Herse, F., Florian Herse, Ralf Dechend, Dudenhausen, J.W., Nele Geusens, Cartwright, J.E., Geusens, N., Verhaegen, I., Jude Morton, Morton, J, Hering, L, Iris Verhaegen, Dominik N. Muller, Dechend, R., Sandra T. Davidge, Joachim W. Dudenhausen, Hering, L., Davidge, S.T., Verlohren, S, Verhaegen, I, Dudenhausen, JW, Friedrich C. Luft, Verlohren, S., Luft, FC   +38 more
core   +1 more source

Comparison of the effects of enamel matrix derivative and mineral trioxide aggregate on the mineralization potential of human cementum-derived cells

Journal of Dental Sciences, 2011
Background/purpose: Cementogenesis is a critical event in the repair of endodontic perforations and the enamel matrix derivative (EMD) was reported to induce cementogenesis when used in periodontal disease.
Hyunsook Chung, Wonkyung Yang, Miri Kim, Hyunjung Ko   +3 more
doaj   +1 more source

Matrix Metalloproteinase‐13 Is Highly Expressed in Destructive Periodontal Disease Activity

Journal of Periodontology, 2006
Background: Matrix metalloproteinases (MMPs) participate in extracellular matrix degradation in physiological and pathological conditions. The available evidence suggests that MMP‐13 plays a significant role in both the initiation and progress of bone resorption.
Hernández Ríos, Emma, Valenzuela, María Antonieta, López Otin, Carlos, Alvarez, Jesús, López, José Manuel, Vernal Astudillo, Rolando, Gamonal Aravena, Jorge Antonio   +6 more
openaire   +5 more sources

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Complex regulation of membrane-type matrix metalloproteinase expression and matrix metalloproteinase-2 activation by concanavalin A in MDA-MB-231 human breast cancer cells [PDF]

, 1995
Matrix Metalloproteinase-2 (MMP-2) is secreted as a zymogen, the activation of which has been associated with metastatic progression in human breast cancer (HBC).
Thompson, Erik W., Yu, Ming, Seiki, Motoharu, Sato, Hiroshi   +3 more
core