Results 241 to 250 of about 700,477 (342)

Matrix Metalloproteinase-2 and CKD Progression: The Chronic Renal Insufficiency Cohort (CRIC) Study. [PDF]

Kidney Med
Baudier RL, Orlandi PF, Yang W, Chen HY, Bansal N, Blackston JW, Chen J, Deo R, Dobre M, He H, He J, Ricardo AC, Shafi T, Srivastava A, Xie D, Susztak K, Feldman HI, Anderson AH, CRIC Study Investigators.   +18 more
europepmc   +1 more source

Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase.

Blood, 2012
B. Detry, Charlotte Erpicum, J. Paupert, S. Blacher, Catherine Maillard, F. Bruyére, Hélène Pendeville, Thibault Remacle, Vincent Lambert, Cédric Balsat, Sandra Ormenese, Françoise Lamaye, E. Janssens, L. Moons, D. Cataldo, F. Kridelka, P. Carmeliet, M. Thiry, J. Foidart, I. Struman, A. Noël   +20 more
semanticscholar   +1 more source

Immunoaffinity‐Mimetic Assembly of Peptide‐Aptamer Conjugates and Stem Cell‐Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair

Advanced Science, EarlyView.
Inspired by antibody‐antigen binding, this study develops an unprecedented immunoaffinity‐mimetic assembly strategy, with Peptide‐AptCD63 conjugates acting as antibody surrogates binding CD63 epitopes on mesenchymal stem cell‐derived exosomes. This creates a hierarchical microstructure intended to synergistically integrate antioxidative and anti ...
Dantong Zheng, Yuxin Bai, Zhibo Liu, Zinan Zhao, Yiming Kong, Yao Xu, Qi Jia, Rongrong Zhu, Yong Hu   +8 more
wiley   +1 more source

Mineralized Cryogel/Hydrogel Constructs to Recapitulate Early Breast Cancer Bone Metastasis In Vitro

Advanced Science, EarlyView.
A new biphasic in vitro cryogel/hydrogel model of early breast cancer bone metastasis provides precise control over microenvironmental cues and microscopic access to the spatiotemporal cancer cell distribution. Deposited bone‐like mineral is observed to strongly impede the effects of biomolecular signals, as evidenced by both colonization profiles and ...
Jana Sievers‐Liebschner, Petra B. Welzel, Maximilian Fusenig, Linda Sturm, Dagmar Pette, Wolfgang Wagermaier, Claudia Fischbach, Peter Fratzl, Carsten Werner   +8 more
wiley   +1 more source

The role of matrix metalloproteinase-2 and miR-196a2 in bronchial asthma pathogenesis and diagnosis. [PDF]

Heliyon
Mohammed OA, Doghish AS, Alamri MMS, Alharthi MH, Alfaifi J, Adam MIE, Alhalafi AH, AlQahtani AAJ, Rezigalla AA, Taura MG, Isa AI, Binafif AF, Attia MA, Elmorsy EA, Yousef AA, Abdel-Reheim MA, Elkady MA.   +16 more
europepmc   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Reduced Degradation of the Chemokine MCP-3 by Matrix Metalloproteinase-2 Exacerbates Myocardial Inflammation in Experimental Viral Cardiomyopathy

Circulation, 2011
D. Westermann, K. Savvatis, D. Lindner, C. Zietsch, P. Becher, E. Hammer, M. Heimesaat, S. Bereswill, U. Völker, F. Escher, A. Riad, J. Plendl, K. Klingel, W. Poller, H. Schultheiss, C. Tschöpe   +15 more
semanticscholar   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Novel role of mitochondrial matrix metalloproteinase-2 in the development of diabetic retinopathy.

Investigative Ophthalmology and Visual Science, 2011
G. Mohammad, R. Kowluru
semanticscholar   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source