Results 261 to 270 of about 246,360 (304)

Matrix metalloproteinase‐2 regulates the expression of tissue inhibitor of matrix metalloproteinase‐2

Clinical and Experimental Pharmacology and Physiology, 2010
Summary1. Matrix metalloproteinases (MMP) are associated with the vascular remodelling seen in atherosclerosis and aneurysm. The activation and activity of MMP‐2 are regulated by the intrinsic tissue inhibitor of MMP‐2 (TIMP‐2). The aim of the present study was to examine whether, conversely, MMP‐2 can affect the gene and protein expression of TIMP‐2.2.
Kaoru, Kimura, Xian Wu, Cheng, Kae, Nakamura, Aiko, Inoue, Lina, Hu, Haizhen, Song, Kenji, Okumura, Akihisa, Iguchi, Toyoaki, Murohara, Masafumi, Kuzuya   +9 more
openaire   +2 more sources

Matrix Metalloproteinase-2 in Dentin Matrix Mineralization

Journal of Endodontics, 2001
In the serum-free culture medium of bovine odontoblasts we detected active gelatinolytic metalloproteinases, matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases A and B). The activity of MMP-2, in particular, appeared suddenly around day 21 in the culture, coinciding with the development of odontoblastic cell processes and the loss of alkaline ...
M, Satoyoshi, A, Kawata, T, Koizumi, K, Inoue, S, Itohara, T, Teranaka, Y, Mikuni-Takagaki   +6 more
openaire   +2 more sources

Matrix metalloproteinase-2 and matrix metalloproteinase-9 in mice with ocular toxocariasis

Parasitology Research, 2019
In ocular toxocariasis, Toxocara canis-induced inflammatory reaction can lead to eye destruction and granuloma, which is formed by immune cell infiltration and concurrent extensive remodeling tissue. Herein, the histomorphology of granuloma and proteinase production in the eye of T. canis-infected BALB/c mice were investigated.
Ling-Yuh Shyu, Ke-Min Chen, Shih-Chan Lai   +2 more
openaire   +2 more sources

Matrix Metalloproteinase 2: Involvement in Keratoconus

European Journal of Ophthalmology, 2000
Purpose The activation of matrix metalloproteinase-2 (MMP-2) is postulated to be a crucial pathogenic factor behind progressive and chronic diseases in which basement membranes are disrupted. An ocular example is keratoconus. The purpose of the present enquiry was therefore to investigate and compare the activities of the MMP-2 secreted by keratocytes ...
V A, Smith, D L, Easty
openaire   +2 more sources

Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis

Journal of Neuroimmunology, 2008
We investigated the association of matrix metalloproteinase-9 (-1562C/T, +279R/Q) and matrix metalloproteinase-2 (-1575G/A, -1306C/T) gene polymorphisms with multiple sclerosis (MS) susceptibility, gender differences and disability in 244 patients and 132 healthy subjects.
Yvonne, Benesová, Anna, Vasků, Pavel, Stourac, Magdalena, Hladíková, Michal, Beránek, Zdenek, Kadanka, Hana, Novotná, Josef, Bednarík   +7 more
openaire   +2 more sources

Matrix metalloproteinase-2 and Matrix metalloproteinase-9 in cholesteatoma and deep meatal skin

Clinical Otolaryngology and Allied Sciences, 1998
A qualitative and quantitative study of the presence of Matrix metalloproteinase-2 (MMP-2) and Matrix metalloproteinase-9 (MMP-9) in cholesteatoma was performed. Ten cholesteatoma and four deep meatal skin specimens were analysed for gelatinase activity at molecular weights corresponding to MMP-2 and MMP-9 using Sodium Dodecyl Sulphate Polyacrylamide ...
A R, Banerjee, R, James, A A, Narula
openaire   +2 more sources

Increased Expression of Matrix Metalloproteinase-2, Matrix Metalloproteinase-9 and Matrix Metalloproteinase-13 in Lesional Skin of Bullous Pemphigoid

International Archives of Allergy and Immunology, 2006
<i>Background:</i> Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 can degrade type IV collagen which is the major component of the basement membrane zone (BMZ). In bullous pemphigoid (BP), the separation occurs within the BMZ. <i>Objective:</i> To evaluate the involvement of MMPs in the pathogenesis of BP, we examined the ...
Yayoi, Niimi, Ruby, Pawankar, Seiji, Kawana   +2 more
openaire   +2 more sources

Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium

Fertility and Sterility, 2002
To investigate expression of matrix metalloproteinase-2 (MMP-2), membranous type 1 matrix metalloproteinase (MT1-MMP), and tissue inhibitor of metalloproteinase-2 (TIMP-2) in ectopic and eutopic endometrium from women with and without endometriosis throughout the menstrual cycle.Molecular studies in human tissue.Reproductive immunology laboratory of a ...
Hye Won, Chung, Ji Young, Lee, Hye-Sung, Moon, Sung Eun, Hur, Mi Hye, Park, Yan, Wen, Mary Lake, Polan   +6 more
exaly   +3 more sources

Matrix metalloproteinases 2 and 9, and extracellular matrix in Kaposi's sarcoma

Dermatologic Therapy, 2010
Matrix metalloproteinases (MMPs) are associated with Kaposi's sarcoma (KS) tumorigenesis and may contribute to the mechanism of KS invasive growth. To date, only a few MMPs have been studied in KS lesions, and exactly which MMPs are involved in KS development and progression remains unanswered.
BONGIORNO, Maria Rita, DOUKAKI, Spyridoula, FERRO, Giuseppe, ARICO', Mario   +3 more
openaire   +3 more sources

Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 Expressions Correlate with the Recurrence of Intracranial Meningiomas

Journal of Neuro-Oncology, 2004
We studied whether or not the expressions of MMP-2 and MMP-9 were correlated with the proliferative potential or recurrence of intracranial meningiomas.The expressions of MMP-2 and MMP-9 of 56 meningioma tissues were examined and scored by immunohistochemistry (IHC).
Masaki, Okada, Keisuke, Miyake, Yoshihito, Matsumoto, Nobuyuki, Kawai, Katsuzo, Kunishio, Seigo, Nagao   +5 more
openaire   +2 more sources