Results 271 to 280 of about 246,360 (304)

Matrix metalloproteinase-9 and matrix metalloproteinase-2 as biomarkers of various courses in multiple sclerosis

Multiple Sclerosis Journal, 2009
Background Matrix metalloproteinases are notable contributors to neuroinflammation and blood-brain barrier disruption in multiple sclerosis (MS). Objective The goal of this study was to determine the serum levels of matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-2 (MMP-2), and their tissue inhibitors (TIMP-1) and (TIMP-2), and to ...
Y, Benesová, A, Vasku, H, Novotná, J, Litzman, P, Stourac, M, Beránek, Z, Kadanka, J, Bednarík   +7 more
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Expression of cyclooxygenase-2, matrix metalloproteinase-2 and matrix metalloproteinase-9 in premenopausal and postmenopausal endometrial polyps

Maturitas, 2008
Cyclooxygenase-2 (COX-2) and matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) are influenced by relative levels of estrogen and are involved in promoting cell proliferation and angiogenesis. The present study investigated expression of COX-2, MMP-2 and MMP-9 in endometrial polyps from premenopausal and postmenopausal women.Premenopausal (n=18) and ...
GÜNEY, Mehmet, ERDEMOĞLU, Evrim, Mungan, Tamer, KARAHAN, Nermin   +3 more
openaire   +5 more sources

Fibrillin-2 Degradation by Matrix Metalloproteinase-2 in Periodontium

Journal of Dental Research, 2007
Elastic system fibers, comprised of microfibrils and tropoelastin, are extracellular components of periodontal tissue. During development, the microfibrils act as a template on which tropoelastin is deposited. However, the process of elastic system fiber remodeling is not fully understood. Therefore, we examined whether matrix metalloproteinases (MMPs)
E, Tsuruga, K, Irie, T, Yajima
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2‐Hydroxyethyl methacrylate as an inhibitor of matrix metalloproteinase‐2

European Journal of Oral Sciences, 2009
This study evaluated the effect of different concentrations of 2‐hydroxyethyl methacrylate (HEMA) on the inhibition of matrix metalloproteinase‐2 (MMP‐2) in vitro. Mouse gingival explants were cultured overnight in Dulbecco’s modified Eagle’s minimal essential medium, following which the expression of secreted enzymes was analyzed by gelatin zymography
Rodrigo V, Carvalho, Fabrício A, Ogliari, Ana P, de Souza, Adriana F, Silva, Cesar L, Petzhold, Sergio R P, Line, Evandro, Piva, Adriana, Etges   +7 more
openaire   +2 more sources

Mechanisms of cytosolic targeting of matrix metalloproteinase‐2

Journal of Cellular Physiology, 2012
AbstractMatrix metalloproteinase‐2 (MMP‐2) is best understood for its biological actions outside the cell. However, MMP‐2 also localizes to intracellular compartments and the cytosol where it has several substrates, including troponin I (TnI). Despite a growing list of cytosolic substrates, we currently do not know the mechanism(s) that give rise to ...
Mohammad A M, Ali, Ava K, Chow, Arulmozhi D, Kandasamy, Xiaohu, Fan, Lori J, West, Bryan D, Crawford, Thomas, Simmen, Richard, Schulz   +7 more
openaire   +2 more sources

Matrix metalloproteinase-2 promoter variability in psoriasis

Archives of Dermatological Research, 2009
The expression of matrix metalloproteinase-2 was observed to be significantly upregulated in psoriasis. The aim of this study was to associate the DNA polymorphic variants in MMP-2 promoter gene with psoriasis and/or with psoriasis phenotypes related to psoriasis and comorbid heredity.
Vladimir, Vasku, Julie, Bienertova Vasku, Veronika, Slonková, Katerina, Kanková, Anna, Vasku   +4 more
openaire   +2 more sources

The Response of Matrix Metalloproteinase-9 and -2 to Exercise

Sports Medicine, 2014
Matrix metalloproteinases (MMPs) are a major group of enzymes that play essential roles in normal functioning of diverse tissues during growth, development, and aging. However, among the MMPs little is known regarding the role of exercise in MMP-9 and MMP-2 function in humans.The aim of this study was to provide a systematic comprehensive review of the
Dahan da Cunha, Nascimento, Rita de Cassia Marqueti, Durigan, Ramires Alsamir, Tibana, João Luiz Quagliotti, Durigan, James Wilfred, Navalta, Jonato, Prestes   +5 more
openaire   +2 more sources

Serum activity of matrix metalloproteinases-2 and-9

Bulletin of Experimental Biology and Medicine, 2006
Matrix metalloproteinases belong to the key effectors of tissue remodeling in health and disease. Matrix metalloproteinases -2 and -9, the most prevalent representatives of this family, are expressed in the endometrium. Chronic endometritis concomitant with sterility and spontaneous abortions is associated with decreased content of matrix ...
G M, Soboleva, A V, Shurshalina, G T, Sukhikh   +2 more
openaire   +2 more sources

Significance of matrix metalloproteinase-2 and matrix metalloproteinase-9 in nonmelanoma skin cancer

Egyptian Journal of Pathology, 2013
Background Matrix metalloproteinases (MMPs) are degradative enzymes that play an important role in tumour progression. Identification of subtypes associated with each cancer type and determination of their source (epithelial or stromal) are crucial steps for effective targeting of MMPs during carcinogenesis. Aim The aim of this study was to evaluate
Riham M. Abu-Zeid, Faten A. Abd El-Kawy, Moshera M. Ali, Ghada A. Abd-El Aziz, Reham M. Rady   +4 more
openaire   +1 more source

Matrix Metalloproteinase 2 (MMP2)

2016
Matrix Metalloproteinases (MMPs) are a family of glycoprotein enzymes, which are zinc-dependent endoproteinases. These degradative enzymes digest the blood-vessel walls to allow endothelial cells to escape and migrate toward the site of the angiogenic stimuli. MMPs play a role in angiogenesis in many different ways; endothelial cell migration caused by
openaire   +1 more source