Results 221 to 230 of about 99,179 (264)

Matrix metalloproteinase‐3 and intracranial arterial dolichoectasia

Annals of Neurology, 2010
AbstractObjectiveIntracranial arterial dolichoectasia (IADE), also called dilatative arteriopathy of the brain, is defined as an increase in length and diameter of intracranial arteries. Abdominal aortic aneurysm and ectasia of coronary arteries have been reported in association with IADE. In both conditions, a dysfunction of matrix metalloproteinases (
Fernando, Pico, Marie-Paule, Jacob, Julien, Labreuche, Nadem, Soufir, Pierre-Jean, Touboul, Joëlle, Benessiano, François, Cambien, Bernard, Grandchamp, Jean-Baptiste, Michel, Pierre, Amarenco   +9 more
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Serum matrix metalloproteinase-3 in systemic sclerosis

Archives of Dermatological Research, 2004
To determine the serum levels of matrix metalloproteinase-3 (MMP-3) in patients with systemic sclerosis (SSc) and investigate their clinical significance in this disease, serum samples from 83 patients with SSc and 30 healthy volunteers were examined by a specific enzyme-linked immunosorbent assay (ELISA).
Masatoshi, Jinnin, Hironobu, Ihn, Yoshihide, Asano, Kenichi, Yamane, Norihito, Yazawa, Kunihiko, Tamaki   +5 more
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Spontaneous metastasis in matrix metalloproteinase 3‐deficient mice

Molecular Carcinogenesis, 2008
AbstractMatrix metalloproteinases (MMPs) have been linked to the metastatic potential of tumor cells due to their ability to degrade the extracellular matrix. MMP‐3 (stromelysin‐1) is upregulated in a wide variety of human tumors. We used the MMTV‐PyMT breast cancer model to determine if MMP‐3 is involved in tumorigenesis and metastatic growth. In this
Juncker-Jensen, Anna, Rømer, John, Pennington, Caroline J, Lund, Leif R, Almholt, Kasper   +4 more
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Substrate specificity of Xenopus matrix metalloproteinase stromelysin-3

International Journal of Molecular Medicine, 2004
The matrix metalloproteinase stromelysin-3 (ST3 or MMP11) was initially identified as a breast carcinoma associated protease and has since been shown to be highly expressed in diverse carcinomas and in developmental processes that involve extensive cell death (apoptosis) and tissue remodeling.
Tosikazu, Amano, Liezhen, Fu, Shelley, Sahu, Meghan, Markey, Yun-Bo, Shi   +4 more
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Circulating matrix metalloproteinase-2 but not matrix metalloproteinase-3, matrix metalloproteinase-9, or tissue inhibitor of metalloproteinase-1 predicts outcome in patients with congestive heart failure

American Heart Journal, 2005
Extracellular matrix remodeling is thought to play an important role in the progression of heart failure (HF). Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are matrix-degrading enzymes that have been demonstrated to influence left ventricular properties and serve as targets of potential anti-remodeling agents ...
Jacob, George, Shuki, Patal, Dov, Wexler, Arie, Roth, David, Sheps, Gad, Keren   +5 more
openaire   +2 more sources

Differential Regulation of Stromelysin-1 (Matrix Metalloproteinase-3) and Matrilysin (Matrix Metalloproteinase-7) in Baboon Endometrium

Journal of the Society for Gynecologic Investigation, 2000
To investigate in vivo expression of matrix metalloproteinase enzymes (MMP), MMP-3 and MMP-7, by the baboon endometrium in relation to the process of tissue remodeling that accompanies menstruation in the primate.Endometrial tissues and uterine fluids obtained from reproductively intact cycling baboons, cycling baboons treated with an anti-progestin ...
K E, Cox, K L, Sharpe-Timms, N, Kamiya, M, Saraf, K M, Donnelly, A T, Fazleabas   +5 more
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The importance of matrix metalloproteinase-3 in respiratory disorders

Expert Review of Respiratory Medicine, 2014
The matrix metalloproteinases (MMPs) encompass a family of zinc-dependent endopeptidases that are secreted into the extracellular environment or remain bound to the cell surface. While MMPs were initially identified based on their ability to degrade collagen and other components of the extracellular matrix, recent studies indicate that their non ...
Cory M, Yamashita, Derek C, Radisky, Yael, Aschner, Gregory P, Downey   +3 more
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Matrix Metalloproteinase-3 Production by Human Degenerated Intervertebral Disc

Journal of SPINAL DISORDERS, 1997
To assess its possible role in the pathophysiology of intervertebral disc degeneration, we investigated the production of matrix metalloproteinase-3 (MMP-3) using human intervertebral disc explant culture. Five normal and 10 degenerated disc specimens were used. The levels of MMP-3 released in the medium were measured with use of an enzyme immunoassay.
O, Nemoto, M, Yamagishi, H, Yamada, T, Kikuchi, H, Takaishi   +4 more
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Matrix Metalloproteinase-3 Differences in Oral and Skin Fibroblasts

Journal of Dental Research, 2007
While skin wounds heal by scarring, wounds of oral mucosa show privileged healing with minimal scar formation. Our hypothesis was that phenotypic differences between oral and skin fibroblasts underlie these differences in healing. The aims of this study were to compare MMP-3 expression by oral and skin fibroblasts and investigate a role for MMP-3 in ...
S T W, McKeown, J J, Barnes, P L, Hyland, F T, Lundy, M J, Fray, C R, Irwin   +5 more
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Serum levels of matrix metalloproteinase‐3 in undifferentiated spondyloarthropathy

Scandinavian Journal of Rheumatology, 2007
Spondyloarthropathy (SpA) is a family of chronic arthritis, characterized by inflammatory back pain, peripheral arthritis, and enthesitis [1].
C-H, Chen, H-T, Liao, H-A, Chen, T-H, Liang, H-P, Wang, C-T, Chou   +5 more
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