Results 51 to 60 of about 19,511,098 (262)

Matrix metalloproteinase-3 (MMP-3)–mediated gene therapy for glaucoma

Science Advances, 2023
Approximately 80 million people globally are affected by glaucoma, with a projected increase to over 110 million by 2040. Substantial issues surrounding patient compliance remain with topical eye drops, and up to 10% of patients become treatment resistant, putting them at risk of permanent vision loss.
O’Callaghan, Jeffrey, Delaney, Conor, O’Connor, Merissa, van Batenburg-Sherwood, Joseph, Schicht, Martin, Lütjen-Drecoll, Elke, Hudson, Natalie, Ni Dhubhghaill, Sorcha, Humphries, Peter, Stanley, Chris, Keravala, Annahita, Chalberg, Thomas, Lawrence, Matthew S., Campbell, Matthew   +13 more
openaire   +6 more sources

Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]

, 2001
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Nelson, EL, Nelson, P. J., Schlöndorff, D, C.D. Cohen, D. Schlöndorff, C.M. Klier, Horuk, R, P.J. Nelson, Schlöndorff, D., Klier, C. M., E.L. Nelson, Nelson, PJ, Cohen, CD, Horuk, R., Cohen, C. D., R. Horuk, Klier, CM, Nelson, E. L.   +17 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Association study between matrix metalloproteinase‐3 gene (MMP3) polymorphisms and ankylosing spondylitis susceptibility

Molecular Genetics & Genomic Medicine, 2019
Background Ankylosing spondylitis (AS) is the second most common cause of inflammatory arthritis worldwide affecting the axial skeleton. Single nucleotide polymorphisms (SNPs) of matrix metalloproteinase‐3 (MMP3) in the development of AS has few been ...
Yong Zhu, Shunan Li, Zhi Huang, Wenhua Xing, Feng Li, Yifeng Da, Jianmin Xue, Manglai Li, Ke Sun, Haiyu Jia, Xuejun Yang   +10 more
doaj   +1 more source

Serum and synovial matrix metalloproteinase-3 as markers of disease activity in early rheumatoid arthritis

Egyptian Rheumatology and Rehabilitation, 2016
Background Matrix metalloprotein ase-3 (MMP-3) is one of the MMPs produced in rheumatoid arthritis (RA) joints. Aim The aim of this study was to evaluate serum and synovial fluid (SF) MMP-3 as markers of disease activity in early RA.
Rasha M Fawzy, Yasser A Abdel Hamid, Mona M Albehesy, Rasha F Aboelmaged   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells

Journal of Experimental & Clinical Cancer Research, 2011
Background matrix metalloproteinases (MMPs) are produced by tumor cells, so they may be associated with tumor progression including invasion, migration, angiogenesis and metastasis.
Yang Li, Shen Lizong, Zhang Wenjie, Xu Yong, Xu Hao, Xu Zekuan   +5 more
doaj   +1 more source

Matrix Metalloproteinase Inhibitors Based on the 3-Mercaptopyrrolidine Core [PDF]

Journal of Medicinal Chemistry, 2013
New series of pyrrolidine mercaptosulfide, 2-mercaptocyclopentane arylsulfonamide, and 3-mercapto-4-arylsulfonamidopyrrolidine matrix metalloproteinase inhibitors (MMPIs) were designed, synthesized, and evaluated. Exhibiting unique properties over other MMPIs (e.g., hydroxamates), these newly reported compounds are capable of modulating activities of ...
Yonghao, Jin, Mark D, Roycik, Dale B, Bosco, Qiang, Cao, Manuel H, Constantino, Martin A, Schwartz, Qing-Xiang Amy, Sang   +6 more
openaire   +2 more sources

Matrix Metalloproteinase 3 as a Valuable Marker for Patients with COVID-19 [PDF]

Journal of Medical Virology, 2020
Background: The situation of the corona virus disease 2019(COVID-19) continues to evolve, our study explored the significance of serum levels of Matrix Metalloproteinase 3 (MMP3) as a marker for patients with COVID-19. Methods: Sixty-two COVID-19 patients in the First Hospital of Hunan University of Chinese Medicine and Loudi Center for Diseases ...
Shi, Shengjie, Su, Min, Shen, Ge, Hu, Yan, Yi, Fan, Zeng, Ziyan, Zhu, Pan, Yang, Gang, Zhou, Hui, Li, Qiong, Xie, Xiaobing   +10 more
openaire   +3 more sources