Results 71 to 80 of about 20,203,639 (294)

Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB. [PDF]

PLoS ONE, 2010
Matrix metalloproteinase-3 (MMP3) is implicated in the pathogenesis and progression of atherosclerotic lesions. Previous studies suggested that MMP3 expression is influenced by a polymorphism (known as the 5A/6A polymorphism) in the promoter of the MMP3 ...
Veronika Souslova, Paul A Townsend, Jelena Mann, Chris M van der Loos, Anna Motterle, Fulvio D'Acquisto, Derek A Mann, Shu Ye   +7 more
doaj   +1 more source

Features of the level of matrix metalloproteinase-2, -3, -9 and tissue inhibitors of metalloproteinases-1, -2, -3, -4 in the aqueous humor of patients with primary open-angle glaucoma

Бюллетень сибирской медицины, 2022
Aim. To study the content of matrix metalloproteinase (MMP)-2, -3, -9 and tissue inhibitors of metalloproteinases (TIMPs) -1, -2, -3, -4 in the aqueous humor of patients with moderate primary open-angle glaucoma (POAG).Materials and methods.
V. V. Chernykh, V. I. Konenkov, O. V. Ermakova, N. B. Orlov, A. N. Trunov   +4 more
doaj   +1 more source

Serum Matrix Metalloproteinase-3 as a Noninvasive Biomarker of Histological Synovitis for Diagnosis of Rheumatoid Arthritis

Mediators of Inflammation, 2014
Objective. To explore the correlation between matrix metalloproteinase- (MMP-) 3 and histological synovitis in rheumatoid arthritis (RA). Methods. Serum MMP-3 of 62 patients with active RA was detected by ELISA.
Jian-Da Ma, Jing-Jing Zhou, Dong-hui Zheng, Le-Feng Chen, Y. Mo, Xiu-Ning Wei, Lijuan Yang, L. Dai   +7 more
semanticscholar   +1 more source

Cell surface engineering of renal cell carcinoma with glycosylphosphatidylinositol-anchored TIMP-1 blocks TGF-beta 1 activation and reduces regulatory ID gene expression [PDF]

, 2012
Tissue inhibitor of metalloproteinase 1 (TIMP-1) controls matrix metalloproteinase activity through 1:1 stoichiometric binding. Human TIMP-1 fused to a glycosylphosphatidylinositol (GPI) anchor (TIMP-1-GPI) shifts the activity of TIMP-1 from the ...
Notohamiprodjo, Susan, Jaeckel, Carsten, Djafarzadeh, Roghieh, Hofstetter, Monika, Nelson, Peter J., Rieth, Nicole   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Matrix metalloproteinase-3 and the 7-joint ultrasound score in the assessment of disease activity and therapeutic efficacy in patients with moderate to severe rheumatoid arthritis

Arthritis Research & Therapy, 2017
Background This study aimed to investigate the reliability and validity of serum matrix metalloproteinase-3 (MMP-3) levels and articular ultrasound (US) scores in assessing disease activity and therapeutic response in rheumatoid arthritis (RA) patients ...
Ling Zhou, Geng Wang, Xin Liu, Jing Song, Ling Chen, Huji Xu   +5 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Higher levels of matrix metalloproteinase-3 in patients with RA reflect disease activity and structural damage

Biomedical Papers, 2017
Aims: To evaluate the serum levels of matrix metalloproteinase-3 (MMP-3) as a potential marker of disease activity and joint damage in 92 patients with rheumatoid arthritis (RA), compared to 24 osteoarthritis (OA) patients and 26 healthy controls ...
Martina Skacelova, Zuzana Hermanova, Pavel Horak, Ahmed Kazi, Katerina Langova   +4 more
doaj   +1 more source

Matrix metalloproteinase-3 causes dopaminergic neuronal death through Nox1-regenerated oxidative stress. [PDF]

PLoS ONE, 2014
In the present study we investigated the interplay between matrix metalloproteinase 3 (MMP3) and NADPH oxidase 1 (Nox1) in the process of dopamine (DA) neuronal death.
Dong-Hee Choi, Ji-Hye Kim, Joo-Ha Seo, Jongmin Lee, Wahn Soo Choi, Yoon-Seong Kim   +5 more
doaj   +1 more source

N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. [In supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells] [PDF]

, 2004
Apoptosis of hepatic stellate cells (HSC) has previously been shown to occur during spontaneous resolution of experimental liver fibrosis. TIMP-1 has also been shown to have a key role because of its ability to inhibit apoptosis of HSC via matrix ...
Iredale, John P., Julian Waung, Derek Mann, R Christopher Benyon, Collins, Jane, Arthur, Michael J.P., Murphy, Frank, Nagase, Hideaki, Hideaki Nagase, John P Iredale, Mann, Derek, Frank Murphy, Waung, Julian, Jane Collins, Benyon, R. Christopher, Michael JP Arthur   +15 more
core   +1 more source