British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum +5 more
wiley +1 more source
Matrix Metalloproteinase-9 (MMP-9) as a Therapeutic Target: Insights into Molecular Pathways and Clinical Applications. [PDF]
PharmaceuticsWolosowicz M, Prokopiuk S, Kaminski TW.
europepmc +1 more source
Bulletin of the Korean Chemical Society, EarlyView.Vitamins could regulate both MMP‐2 and MMP‐9 expression and activity through transcriptional and MAPK signaling pathway modulation. This study highlights the potential of vitamins as low‐toxicity therapeutic or adjunct agents for targeting MMP‐mediated cancer progression. Abstract Matrix metalloproteinases (MMP‐2 and MMP‐9) are key regulators of cancer
Yen Thi Nguyen +5 more
wiley +1 more source
Integrative computational, synthetic, experimental evaluation of targeted inhibitors against matrix metalloproteinase-9: Toward precision modulation of proteolytic activity. [PDF]
PLoS OneRashid ZA +4 more
europepmc +1 more source
New opportunities for bioscaffold‐enabled spinal cord injury repair
BMEMat, EarlyView.Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi +11 more
wiley +1 more source
The causal effect of matrix metalloproteinase 9 on interstitial lung disease risk mediated by effector memory double negative T cells: A mediation Mendelian randomization study. [PDF]
Medicine (Baltimore)Ren Q, Sun F, Yang L, Su D, Shen M.
europepmc +1 more source
Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment
BMEMat, EarlyView.Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan +8 more
wiley +1 more source
Streptococcus pneumoniae infection is associated with matrix metalloproteinase-9 in lung cancer progression and brain metastases. [PDF]
Sci RepGao L, Dhilipkannah P, Jiang F.
europepmc +1 more source