Results 221 to 230 of about 116,728 (258)
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Platelets and matrix metalloproteinases
Thrombosis and Haemostasis, 2013SummaryMatrix metalloproteinases (MMPs) and their inhibitors essentially contribute to a variety of pathophysiologies by modulating cell migration, tissue degradation and inflammation. Platelet-associated MMP activity appears to play a major role in these processes.
P, Seizer, A E, May
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Matrix metalloproteinases in immunity
The Journal of Immunology, 1996Abstract Matrix metalloproteinases (MMPs) are a family of zinc-containing endo-proteinases that share structural domains but differ in substrate specificity, cellular sources, and inducibility. Macrophage production and secretion of large quantities of many MMPs, after contact with matrix proteins, is enhanced by surface determinants ...
E J, Goetzl, M J, Banda, D, Leppert
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Matrix Metalloproteinases in Atherothrombosis
Progress in Cardiovascular Diseases, 2010The metalloproteinases (MMPs, matrixins) are zinc-containing endopeptidases involved in the metabolism of extracellular matrix as well as in the cleavage of other proteins. The MMP family currently consists of 28 enzymes with somewhat different activities.
Magnus, Bäck +2 more
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Matrix Metalloproteinases and the Thyroid
Thyroid, 2000Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade components of the extracellular matrix (ECM) and basement membrane. They play a critical role in many physiological and pathological processes, such as tumor metastasis. The original concept-that MMP activity during metastasis is restricted solely to invasion of the basement membrane
Z, Kraiem, S, Korem
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Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer
Seminars in Oncology, 2002Preclinical studies have provided evidence that matrix metalloproteinases (MMPs), a family of zinc-containing proteolytic enzymes, facilitate tumor invasion, the establishment of metastases, and the promotion of tumor-related angiogenesis. Matrix metalloproteinase inhibitors (MMPIs) have been shown to inhibit tumor growth and dissemination in ...
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Matrix Metalloproteinases and Endometriosis
Seminars in Reproductive Medicine, 2003Retrograde menstruation represents a plausible explanation for the development of most cases of endometriosis; nevertheless, additional factors must contribute to the development of disease in only 10 to 20% of women. The discriminating factor(s) in determining the development of active endometriosis probably involves a complex array of potentially ...
Kevin G, Osteen +2 more
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Matrix Metalloproteinases in Invertebrates
Protein & Peptide Letters, 2020Matrix Metalloproteinases (MMPs) belong to a family of metal-dependent endopeptidases which contain a series of conserved pro-peptide domains and catalytic domains. MMPs have been widely found in plants, animals, and microorganisms. MMPs are involved in regulating numerous physiological processes, pathological processes, and immune responses.
Xi Liu +8 more
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Matrix metalloproteinases in repair
Wound Repair and Regeneration, 1999During repair, many different matrix metalloproteinases are produced by multiple cell types residing in various compartments within the wound environment. This diversity of enzymes, coupled with discreet cellular expression, implies that different matrix metalloproteinases serve different functions, acting on a variety of substrates, during wound ...
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Matrix degrading metalloproteinases
Journal of Neuro-Oncology, 1994Matrix degrading metalloproteinases are enzymes that degrade proteins in tissue extracellular matrices. These proteinases exhibit specific, well defined properties that allow them to be classified into a family of enzymes. They are secreted by various cell types as the cells effect their surrounding extracellular matrix.
B W, Ennis, L M, Matrisian
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Matrix metalloproteinases in pneumonia
Clinica Chimica Acta, 2014Pneumonia is a worldwide infectious disease that is associated with significant morbidity and mortality and is the most common fatal infection acquired in hospitals. Despite advances in preventive strategies, such as antibiotic therapies and intensive care, the mortality rate still requires substantial improvement.
Ting-Yen, Chiang +3 more
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