Results 1 to 10 of about 218,177 (169)
Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics
Cells, 2020 The metalloproteinase (MP) family of zinc-dependent proteases, including matrix metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) plays a crucial role in ...
Maryam Raeeszadeh-Sarmazdeh, Linh D Do
exaly +3 more sources
Matrix Effectors in the Pathogenesis of Keratinocyte-Derived Carcinomas
Frontiers in Medicine, 2022 Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), referred to as keratinocyte carcinomas, are skin cancer with the highest incidence.
Rafaela-Maria Kavasi +12 more
doaj +1 more source
Biomedical Photonics, 2022 The effect of photodynamic therapy (PDT) on the level of matrix metalloproteinases in squamous cell skin cancer (SCSC) was studied. The study involved 202 people, including 185 patients with SCSC, who were on outpatient and inpatient treatment in medical
V. V. Maslyakov +3 more
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Cell–Matrix Interactions in the Eye: From Cornea to Choroid
Cells, 2021 The extracellular matrix (ECM) plays a crucial role in all parts of the eye, from maintaining clarity and hydration of the cornea and vitreous to regulating angiogenesis, intraocular pressure maintenance, and vascular signaling.
Andrew E. Pouw +8 more
doaj +1 more source
Marine Drugs, 2022 Nature-based and sustainably sourced cosmetics have been dominating the area of skincare products worldwide. Due to their antioxidant and antiaging properties, compounds from cyanobacteria, such as carotenoids and phycobiliproteins, may replace synthetic
Janaína Morone +5 more
doaj +1 more source
Cosmetics, 2023 Skin aging and wrinkle formation are processes that are largely influenced by the overexpression of enzymes like tyrosinase, elastase, and collagenase. This study aimed to validate the skin anti-aging properties of phytochemicals from Peperomia pellucida
Babatunji Emmanuel Oyinloye +9 more
doaj +1 more source
Lymphangioleiomyomatosis: Searching for potential biomarkers
Frontiers in Medicine, 2023 BackgroundVascular endothelial growth factor-D (VEGF-D) is the most commonly used biomarker for diagnosing lymphangioleiomyomatosis (LAM). However, lung biopsy is often necessary as well; therefore, defining new biomarkers for LAM is crucial.
Eva Revilla-López +20 more
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Frontiers in Cellular and Infection Microbiology, 2022 Chronic Chagas disease (CCC) is an inflammatory dilated cardiomyopathy with a worse prognosis compared to other cardiomyopathies. We show the expression and activity of Matrix Metalloproteinases (MMP) and of their inhibitors TIMP (tissue inhibitor of ...
Monique Andrade Baron +27 more
doaj +1 more source
Purification of a fragment obtained by autolysis of a PIIIb-SVMP from Bothrops alternatus venom [PDF]
, 2018 Snake Venom Metalloproteinases (SVMPs) represent 43.1% of the components in Bothrops alternatus venom and play an important role in envenomation. Disintegrins and disintegrin-like domains are released by proteolytic processing of PII and PIII classes of ...
Acosta, Ofelia Cristina +9 more
core +1 more source
Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution
Molecules, 2021 For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep investigation. Since its discovery as the tumor necrosis factor convertase, it has been considered a major drug target, especially in the context of inflammatory ...
Matteo Calligaris +6 more
doaj +1 more source