Results 1 to 10 of about 32,940 (209)

Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics

Cells, 2020
The metalloproteinase (MP) family of zinc-dependent proteases, including matrix metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) plays a crucial role in ...
Linh D, Maryam Raeeszadeh Sarmazdeh
exaly   +3 more sources

Matrix Effectors in the Pathogenesis of Keratinocyte-Derived Carcinomas

Frontiers in Medicine, 2022
Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), referred to as keratinocyte carcinomas, are skin cancer with the highest incidence.
Rafaela-Maria Kavasi, Monica Neagu, Monica Neagu, Monica Neagu, Carolina Constantin, Carolina Constantin, Carolina Constantin, Adriana Munteanu, Adriana Munteanu, Mihaela Surcel, Aristidis Tsatsakis, George N. Tzanakakis, Dragana Nikitovic   +12 more
doaj   +1 more source

Influence of photodynamic therapy on the level of matrix metalloproteinases in squamous cell skin cancer

Biomedical Photonics, 2022
The effect of photodynamic therapy (PDT) on the level of matrix metalloproteinases in squamous cell skin cancer (SCSC) was studied. The study involved 202 people, including 185 patients with SCSC, who were on outpatient and inpatient treatment in medical
V. V. Maslyakov, D. Yu. Grebnev, A. A. Tsymbal, L. M. Kim   +3 more
doaj   +1 more source

Cell–Matrix Interactions in the Eye: From Cornea to Choroid

Cells, 2021
The extracellular matrix (ECM) plays a crucial role in all parts of the eye, from maintaining clarity and hydration of the cornea and vitreous to regulating angiogenesis, intraocular pressure maintenance, and vascular signaling.
Andrew E. Pouw, Mark A. Greiner, Razek G. Coussa, Chunhua Jiao, Ian C. Han, Jessica M. Skeie, John H. Fingert, Robert F. Mullins, Elliott H. Sohn   +8 more
doaj   +1 more source

Cosmetic Application of Cyanobacteria Extracts with a Sustainable Vision to Skincare: Role in the Antioxidant and Antiaging Process

Marine Drugs, 2022
Nature-based and sustainably sourced cosmetics have been dominating the area of skincare products worldwide. Due to their antioxidant and antiaging properties, compounds from cyanobacteria, such as carotenoids and phycobiliproteins, may replace synthetic
Janaína Morone, Graciliana Lopes, João Morais, Jorge Neves, Vítor Vasconcelos, Rosário Martins   +5 more
doaj   +1 more source

Skin Anti-Aging Potentials of Phytochemicals from Peperomia pellucida against Selected Metalloproteinase Targets: An In Silico Approach

Cosmetics, 2023
Skin aging and wrinkle formation are processes that are largely influenced by the overexpression of enzymes like tyrosinase, elastase, and collagenase. This study aimed to validate the skin anti-aging properties of phytochemicals from Peperomia pellucida
Babatunji Emmanuel Oyinloye, Emmanuel Ayodeji Agbebi, Oluwaseun Emmanuel Agboola, Chukwudi Sunday Ubah, Olutunmise Victoria Owolabi, Raphael Taiwo Aruleba, Sunday Amos Onikanni, Jerius Nkwuda Ejeje, Basiru Olaitan Ajiboye, Olaposi Idowu Omotuyi   +9 more
doaj   +1 more source

Lymphangioleiomyomatosis: Searching for potential biomarkers

Frontiers in Medicine, 2023
BackgroundVascular endothelial growth factor-D (VEGF-D) is the most commonly used biomarker for diagnosing lymphangioleiomyomatosis (LAM). However, lung biopsy is often necessary as well; therefore, defining new biomarkers for LAM is crucial.
Eva Revilla-López, Eva Revilla-López, Victoria Ruiz de Miguel, Manuel López-Meseguer, Cristina Berastegui, Meritxell Boada-Pérez, Alberto Mendoza-Valderrey, Marta Arjona-Peris, Marta Zapata-Ortega, Victor Monforte, Victor Monforte, Carlos Bravo, Carlos Bravo, Antonio Roman, Antonio Roman, Susana Gómez-Ollés, Susana Gómez-Ollés, Susana Gómez-Ollés, Berta Sáez-Giménez, Berta Sáez-Giménez, Berta Sáez-Giménez   +20 more
doaj   +1 more source

Matrix Metalloproteinase 2 and 9 Enzymatic Activities are Selectively Increased in the Myocardium of Chronic Chagas Disease Cardiomyopathy Patients: Role of TIMPs

Frontiers in Cellular and Infection Microbiology, 2022
Chronic Chagas disease (CCC) is an inflammatory dilated cardiomyopathy with a worse prognosis compared to other cardiomyopathies. We show the expression and activity of Matrix Metalloproteinases (MMP) and of their inhibitors TIMP (tissue inhibitor of ...
Monique Andrade Baron, Monique Andrade Baron, Monique Andrade Baron, Ludmila Rodrigues Pinto Ferreira, Ludmila Rodrigues Pinto Ferreira, Ludmila Rodrigues Pinto Ferreira, Ludmila Rodrigues Pinto Ferreira, Priscila Camillo Teixeira, Priscila Camillo Teixeira, Priscila Camillo Teixeira, Ana Iochabel Soares Moretti, Ronaldo Honorato Barros Santos, Amanda Farage Frade, Amanda Farage Frade, Amanda Farage Frade, Andréia Kuramoto, Andréia Kuramoto, Victor Debbas, Luiz Alberto Benvenuti, Fabio Antônio Gaiotto, Fernando Bacal, Pablo Pomerantzeff, Christophe Chevillard, Jorge Kalil, Jorge Kalil, Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto   +27 more
doaj   +1 more source

Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity

Platelets, 2023
Platelet-specific collagen receptor glycoprotein (GP)VI is stable on the surface of circulating platelets but undergoes ectodomain cleavage on activated platelets.
Christine Shu Mei Lee, Amandeep Kaur, Samantha J. Montague, Sarah M. Hicks, Robert K. Andrews, Elizabeth E. Gardiner   +5 more
doaj   +1 more source

MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis

Nature Communications, 2018
Matrix metalloproteinases (MMP) are involved in vascular remodeling associated with plaque progression. Little is known about their immune regulatory role in vascular disorders.
Cristina Clemente, Cristina Rius, Laura Alonso-Herranz, Mara Martín-Alonso, Ángela Pollán, Emilio Camafeita, Fernando Martínez, Rubén A. Mota, Vanessa Núñez, Cristina Rodríguez, Motoharu Seiki, José Martínez-González, Vicente Andrés, Mercedes Ricote, Alicia G. Arroyo   +14 more
doaj   +1 more source