Results 11 to 20 of about 218,326 (315)
Metalloproteinases and Metalloproteinase Inhibitors in Age-Related Diseases [PDF]
Current Pharmaceutical Design, 2014 Degradation of the extracellular matrix is an important feature of embryonic development, morphogenesis, angiogenesis, tissue repair and remodeling. It is precisely regulated under physiological conditions, but when dysregulated it becomes a cause of many diseases, including atherosclerosis, osteoarthritis, diabetic vascular complications, and ...
GARGIULO, Simona +3 more
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Journal of UOEH, 1997 Matrix-degrading enzymes, matrix metalloproteinases, are members of a unique family of Zinc-binding endopeptidases that are responsible for the metabolism of extracellular components in the tissue stroma. Their controlled expression is essential for normal processes such as wound healing and tissue remodeling, including embryogenesis.
Parsons, S. L. +4 more
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The ADAMTS metalloproteinases [PDF]
Biochemical Journal, 2005 The ADAMTSs (adisintegrin and metalloproteinase with thrombospondin motifs) are a group of proteases that are found both in mammals and invertebrates. Since the prototype ADAMTS-1 was first described in 1997, there has been a rapidly expanding body of literature describing this gene family and the proteins they encode.
Porter, Sarah +3 more
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010 Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatin and casein are major components cleaved by MMPs.
O, Zitka +7 more
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Metalloproteinases in melanoma
European Journal of Cell Biology, 2014 Tumour cell adhesion, motility, proteolytic activities and cell receptors have important roles in cancer invasion. These processes are involved from early development of melanoma within the epidermis, to tumour cell invasion of the underlying tissue until intravasation of lymphatic or blood vessels, and thereafter, dissemination into distant organs ...
Nives, Moro +2 more
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Matrix metalloproteinases in liver injury, repair and fibrosis. [PDF]
, 2015 The liver is a large highly vascularized organ with a central function in metabolic homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to various insults which can cause cell death and hepatic dysfunction ...
Baber, John +3 more
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Osteoarthritis - epidemiology, risk factors and methods of conservative treatment
Journal of Education, Health and Sport, 2023 Osteoarthritis is one of the most common chronic diseases, which is characterized by the destruction of joint cartilage and leads to changes in the structure of other joint elements, the formation of osteophytes and the development of inflammation in ...
Damian Jasłowski +9 more
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A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren’s Disease [PDF]
, 2007 Dupuytren’s disease (DD) is a common fibrotic condition of the palmar fascia, leading to deposition of collagen-rich cords and finger contractions. The metzincin superfamily contains key enzymes in the turnover of collagen and other extracellular matrix ...
Adrian J. Chojnowski +48 more
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Matrix metalloproteinases at key junctions in the pathomechanism of stroke [PDF]
, 2011 Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Amento +91 more
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Nature Communications, 2018 Matrix metalloproteinases (MMP) are involved in vascular remodeling associated with plaque progression. Little is known about their immune regulatory role in vascular disorders.
Cristina Clemente +14 more
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