Results 11 to 20 of about 125,457 (165)
Journal of UOEH, 1997 Matrix-degrading enzymes, matrix metalloproteinases, are members of a unique family of Zinc-binding endopeptidases that are responsible for the metabolism of extracellular components in the tissue stroma. Their controlled expression is essential for normal processes such as wound healing and tissue remodeling, including embryogenesis.
Parsons, S. L. +4 more
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010 Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatin and casein are major components cleaved by MMPs.
O, Zitka +7 more
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The ADAMTS metalloproteinases [PDF]
Biochemical Journal, 2005 The ADAMTSs (adisintegrin and metalloproteinase with thrombospondin motifs) are a group of proteases that are found both in mammals and invertebrates. Since the prototype ADAMTS-1 was first described in 1997, there has been a rapidly expanding body of literature describing this gene family and the proteins they encode.
Porter, Sarah +3 more
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Metalloproteinases in melanoma
European Journal of Cell Biology, 2014 Tumour cell adhesion, motility, proteolytic activities and cell receptors have important roles in cancer invasion. These processes are involved from early development of melanoma within the epidermis, to tumour cell invasion of the underlying tissue until intravasation of lymphatic or blood vessels, and thereafter, dissemination into distant organs ...
Nives, Moro +2 more
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Osteoarthritis - epidemiology, risk factors and methods of conservative treatment
Journal of Education, Health and Sport, 2023 Osteoarthritis is one of the most common chronic diseases, which is characterized by the destruction of joint cartilage and leads to changes in the structure of other joint elements, the formation of osteophytes and the development of inflammation in ...
Damian Jasłowski +9 more
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Nature Communications, 2018 Matrix metalloproteinases (MMP) are involved in vascular remodeling associated with plaque progression. Little is known about their immune regulatory role in vascular disorders.
Cristina Clemente +14 more
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Impact of Extracellular Matrix Components to Renal Cell Carcinoma Behavior
Frontiers in Oncology, 2020 Renal cell carcinoma (RCC) represents the main renal tumors and are highly metastatic. They are heterogeneous tumors and are subdivided in 12 different subtypes where clear cell RCC (ccRCC) represents the main subtype. Tumor extracellular matrix (ECM) is
Sandra Majo +8 more
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Frontiers in Nutrition, 2021 Matrix metalloproteinases (MMP) and their endogenous inhibitor, the tissue inhibitor of metalloproteinases (TIMP), are expressed in many different cell types and play an important role in physiologic and pathological degradation of extracellular matrix ...
Carla Barbosa Nonino +10 more
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Frontiers in Cell and Developmental Biology, 2019 Craniofacial development comprises a complex process in humans in which failures or disturbances frequently lead to congenital anomalies. Cleft lip with/without palate (CL/P) is a common congenital anomaly that occurs due to variations in craniofacial ...
Katiúcia Batista Silva Paiva +7 more
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Metalloproteinases and Metalloproteinase Inhibitors in Age-Related Diseases [PDF]
Current Pharmaceutical Design, 2014 Degradation of the extracellular matrix is an important feature of embryonic development, morphogenesis, angiogenesis, tissue repair and remodeling. It is precisely regulated under physiological conditions, but when dysregulated it becomes a cause of many diseases, including atherosclerosis, osteoarthritis, diabetic vascular complications, and ...
Simona, Gargiulo +3 more
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