Results 31 to 40 of about 125,457 (165)

Perfil de proteases de lesões cutâneas experimentais em camundongos tratadas com a lectina isolada das sementes de Canavalia brasiliensis Proteases profile of skin wounds treated with lectin from Canavalia brasiliensis seeds

Ciência Rural, 2009
O objetivo deste estudo foi determinar o perfil de proteases em lesões cutâneas experimentais tratadas com a lectina isolada das sementes da Canavalia brasiliensis (ConBr) livre e conjugada com o seu açúcar específico.
Flávio de Oliveira Silva, Rosângela Vidal de Souza Araújo, Giuliana Viegas Schirato, Edson Holanda Teixeira, Mário Ribeiro de Melo Júnior, Benildo de Sousa Cavada, José Luiz de Lima-Filho, Ana Maria dos Anjos Carneiro-Leão, Ana Lúcia Figueiredo Porto   +8 more
doaj   +1 more source

The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

Toxins, 2021
A global strategy, under the coordination of the World Health Organization, is being unfolded to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure safe and effective treatments.
José María Gutiérrez, Laura-Oana Albulescu, Rachel H. Clare, Nicholas R. Casewell, Tarek Mohamed Abd El-Aziz, Teresa Escalante, Alexandra Rucavado   +6 more
doaj   +1 more source

Association Between Plasma ADAMTS-7 Levels and Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus

Medicina
A disintegrin and metalloproteinase with thrombospondin motifs-7 (ADAMTS-7) belongs to the family of metalloproteinases that contributes to tissue homeostasis during morphogenesis and reproduction. These metalloproteinases regulate various cell functions
Asimina Ganotopoulou, Emmanouil Korakas, Loukia Pliouta, Aikaterini Kountouri, Sotirios Pililis, Stamatios Lampsas, Ignatios Ikonomidis, Loukianos S. Rallidis, Athanasia Papazafiropoulou, Andreas Melidonis, Vaia Lambadiari   +10 more
doaj   +1 more source

Lonidamine Causes Inhibition of Angiogenesis-Related Endothelial Cell Functions

Neoplasia: An International Journal for Oncology Research, 2004
The aim of this study was to assess whether lonidamine (LND) interferes with some steps in angiogenesis progression. We report here, for the first time, that LND inhibited angiogenic-related endothelial cell functions in a dose-dependent manner (1-50 μg ...
Donatella Del Bufalo, Daniela Trisciuoglio, Marco Scarsella, Giulia D'Amati, Antonio Candiloro, Angela Iervolino, Carlo Leonetti, Gabriella Zupi   +7 more
doaj   +1 more source

The ADAM metalloproteinases

Molecular Aspects of Medicine, 2008
The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane and secreted proteins with important roles in regulating cell phenotype via their effects on cell adhesion, migration, proteolysis and signalling. Though all ADAMs contain metalloproteinase domains, in humans only 13 of the 21 genes in the family encode functional
Edwards, Dylan R., Handsley, Madeleine M., Pennington, Caroline J.   +2 more
openaire   +3 more sources

Metalloproteinases and tissue inhibitors of metalloproteinases in exudative pleural effusions [PDF]

European Respiratory Journal, 2005
The aim of this study was to assess the expression of several metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in exudative pleural effusions, and their relationship with inflammatory and fibrinolytic mediators in parapneumonic effusions.The study included 51 parapneumonic effusions (30 empyema or complicated parapneumonic,
D, Iglesias, J, Alegre, C, Alemán, E, Ruíz, T, Soriano, L I, Armadans, R M, Segura, A, Anglés, J, Monasterio, T Fernández, de Sevilla   +9 more
openaire   +2 more sources

A Strong Decrease in TIMP3 Expression Mediated by the Presence of miR-17 and 20a Enables Extracellular Matrix Remodeling in the NSCLC Lesion Surroundings

Frontiers in Oncology, 2019
Background: Lung cancer is one of the most common causes of death worldwide with a relatively high fatality rate and a mean 5-years survival of about 18%.
Karolina H. Czarnecka, Karolina H. Czarnecka, Bartosz Szmyd, Magda Barańska, Marcin Kaszkowiak, Jacek Kordiak, Adam Antczak, Dorota Pastuszak-Lewandoska, Ewa Brzeziańska-Lasota   +8 more
doaj   +1 more source

Metalloproteinases in atherosclerosis [PDF]

European Journal of Pharmacology, 2017
Atherosclerosis underlies most cardiovascular diseases, and is accepted as a primary cause of mortality worldwide. Proteases have been implicated in the development and progression of atherosclerosis, due to their ability to provoke focal destruction of the vascular extracellular matrix.
openaire   +4 more sources

Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders

Frontiers in Cellular Neuroscience, 2017
The extracellular matrix (ECM) and membrane proteolysis play a key role in structural and functional synaptic plasticity associated with development and learning.
Patrycja Brzdak, Patrycja Brzdak, Daria Nowak, Daria Nowak, Grzegorz Wiera, Grzegorz Wiera, Jerzy W. Mozrzymas, Jerzy W. Mozrzymas   +7 more
doaj   +1 more source

An Analysis of the Content of Metalloproteinases in the Intestinal Wall of Patients with Crohn’s Disease

Life, 2023
One of the inflammatory bowel diseases is Crohn’s disease. Although this term has been used in the medical community since 1932, a significant increase in the number of publications occurs at the end of the 20th century and the beginning of the 21st ...
Grzegorz Chrzanowski, Grzegorz Pasternak, David Aebisher, Klaudia Dynarowicz, Angelika Myśliwiec, Dorota Bartusik-Aebisher, Barbara Sosna, Grzegorz Cieślar, Aleksandra Kawczyk-Krupka, Rafał Filip   +9 more
doaj   +1 more source