Results 51 to 60 of about 218,326 (315)

Metalloproteinases and tissue inhibitors of metalloproteinases in exudative pleural effusions [PDF]

European Respiratory Journal, 2005
The aim of this study was to assess the expression of several metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in exudative pleural effusions, and their relationship with inflammatory and fibrinolytic mediators in parapneumonic effusions.The study included 51 parapneumonic effusions (30 empyema or complicated parapneumonic,
D, Iglesias, J, Alegre, C, Alemán, E, Ruíz, T, Soriano, L I, Armadans, R M, Segura, A, Anglés, J, Monasterio, T Fernández, de Sevilla   +9 more
openaire   +2 more sources

A Strong Decrease in TIMP3 Expression Mediated by the Presence of miR-17 and 20a Enables Extracellular Matrix Remodeling in the NSCLC Lesion Surroundings

Frontiers in Oncology, 2019
Background: Lung cancer is one of the most common causes of death worldwide with a relatively high fatality rate and a mean 5-years survival of about 18%.
Karolina H. Czarnecka, Karolina H. Czarnecka, Bartosz Szmyd, Magda Barańska, Marcin Kaszkowiak, Jacek Kordiak, Adam Antczak, Dorota Pastuszak-Lewandoska, Ewa Brzeziańska-Lasota   +8 more
doaj   +1 more source

An Analysis of the Content of Metalloproteinases in the Intestinal Wall of Patients with Crohn’s Disease

Life, 2023
One of the inflammatory bowel diseases is Crohn’s disease. Although this term has been used in the medical community since 1932, a significant increase in the number of publications occurs at the end of the 20th century and the beginning of the 21st ...
Grzegorz Chrzanowski, Grzegorz Pasternak, David Aebisher, Klaudia Dynarowicz, Angelika Myśliwiec, Dorota Bartusik-Aebisher, Barbara Sosna, Grzegorz Cieślar, Aleksandra Kawczyk-Krupka, Rafał Filip   +9 more
doaj   +1 more source

Integrin α2β1 Expression Regulates Matrix Metalloproteinase-1-Dependent Bronchial Epithelial Repair in Pulmonary Tuberculosis. [PDF]

, 2018
Pulmonary tuberculosis (TB) is caused by inhalation of Mycobacterium tuberculosis, which damages the bronchial epithelial barrier to establish local infection.
Akif A. Khawaja, Catherine W. M. Ong, Catherine W. M. Ong, Deborah L. W. Chong, Joanna C. Porter, Jon S. Friedland, Naomi J. Guppy, Sara Brilha, Sara Brilha   +8 more
core   +6 more sources

The ADAM metalloproteinases

Molecular Aspects of Medicine, 2008
The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane and secreted proteins with important roles in regulating cell phenotype via their effects on cell adhesion, migration, proteolysis and signalling. Though all ADAMs contain metalloproteinase domains, in humans only 13 of the 21 genes in the family encode functional
Edwards, Dylan R., Handsley, Madeleine M., Pennington, Caroline J.   +2 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders

Frontiers in Cellular Neuroscience, 2017
The extracellular matrix (ECM) and membrane proteolysis play a key role in structural and functional synaptic plasticity associated with development and learning.
Patrycja Brzdak, Patrycja Brzdak, Daria Nowak, Daria Nowak, Grzegorz Wiera, Grzegorz Wiera, Jerzy W. Mozrzymas, Jerzy W. Mozrzymas   +7 more
doaj   +1 more source

Dynamic changes of mmp-9 plasma levels correlate with jvc reactivation and immune activation in natalizumab-treated multiple sclerosis patients [PDF]

, 2019
The aim of the study was to investigate the changes of matrix metalloproteinase (MMP)-2 and MMP-9 plasma levels during natalizumab treatment and their correlation with JC virus (JCV) reactivation and T-lymphocyte phenotypic modifications in peripheral ...
Ciardi, Maria Rosa, Cortese, Antonio, D’Agostino, Claudia, Francia, Ada, Frontoni, Marco, Iannetta, Marco, Latronico, Tiziana, Liuzzi, Grazia Maria, Mastroianni, Claudio Maria, Pati, Ilaria, Pietropaolo, Valeria, Pontecorvo, Simona, Prezioso, Carla, Vullo, Vincenzo, Zingaropoli, Maria Antonella   +14 more
core   +3 more sources

Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox [PDF]

, 2020
Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases.
Bicknell, Andrew B., Lakshminarayanan, Karthik, Layfield, Harry J., Mehmi, Amita, Patel, Ketan, Ravishankar, Divyashree, Salim, Anika, Sonavane, Medha, Trim, Steven A., Vaiyapuri, Rajendran, Vaiyapuri, Sakthivel, Vallance, Thomas M., Williams, Harry F.   +12 more
core   +1 more source

Metalloproteinases in atherosclerosis [PDF]

European Journal of Pharmacology, 2017
Atherosclerosis underlies most cardiovascular diseases, and is accepted as a primary cause of mortality worldwide. Proteases have been implicated in the development and progression of atherosclerosis, due to their ability to provoke focal destruction of the vascular extracellular matrix.
openaire   +4 more sources