Results 41 to 50 of about 125,457 (165)

Trypanosoma cruzi Induces the PARP1/AP-1 Pathway for Upregulation of Metalloproteinases and Transforming Growth Factor β in Macrophages: Role in Cardiac Fibroblast Differentiation and Fibrosis in Chagas Disease

mBio, 2020
Chagas disease (CD), caused by Trypanosoma cruzi, is a degenerative heart condition. In the present study, we investigated the role of poly [ADP-ribose] polymerase 1/activator protein 1 (PARP1/AP-1) in upregulation of profibrotic macrophages (Mϕ) and ...
Subhadip Choudhuri, Nisha Jain Garg
doaj   +1 more source

Inhibition of metalloproteinases in therapy for severe lung injury due to COVID-19

Medicine in Drug Discovery, 2020
Since its first appearance in December 2019 in the Chinese province of Wuhan, COVID-19 has spread rapidly throughout the world and poses a serious threat to public health.
B. Solun, MD, Y. Shoenfeld, MD, FRCP, MaACR   +1 more
doaj   +1 more source

Ação do extrato etanólico da casca do pequi (Caryocar brasiliense) na cardiotoxicidade crônica induzida por doxorrubicina em ratos

Pesquisa Veterinária Brasileira
RESUMO: A doxorrubicina (DOX) é um quimioterápico utilizado no tratamento de neoplasias malignas, porém possui a cardiotoxicidade como efeito colateral.
Léa R. Moura, Stiwens R.T. Orpinelli, Julia H. Sousa, Mariana B.R. Faleiro, Edemilson C. Conceição, Denis M. Sugita, Marcelo E. Beletti, Veridiana M.B.D. Moura   +7 more
doaj   +1 more source

Integrated analysis of multiple microarray studies to establish differential diagnostic models of Crohn’s disease and ulcerative colitis based on a metalloproteinase-associated module

Frontiers in Immunology, 2022
BackgroundThe ulcerative colitis (UC) and Crohn’s disease (CD) subtypes of inflammatory bowel disease (IBD) are autoimmune diseases influenced by multiple complex factors.
Jiang Deng, Jiang Deng, Ning Zhao, Ning Zhao, Li-ping Lv, Li-ping Lv, Ping Ma, Ping Ma, Yang-yang Zhang, Yang-yang Zhang, Jin-bo Xu, Jin-bo Xu, Xi-peng Zhou, Xi-peng Zhou, Zi-an Chen, Zi-an Chen, Yan-yu Zhang, Yan-yu Zhang   +17 more
doaj   +1 more source

Evaluation of Proteoforms of the Transmembrane Chemokines CXCL16 and CX3CL1, Their Receptors, and Their Processing Metalloproteinases ADAM10 and ADAM17 in Proliferative Diabetic Retinopathy

Frontiers in Immunology, 2021
The transmembrane chemokine pathways CXCL16/CXCR6 and CX3CL1/CX3CR1 are strongly implicated in inflammation and angiogenesis. We investigated the involvement of these chemokine pathways and their processing metalloproteinases ADAM10 and ADAM17 in the ...
Ahmed M. Abu El-Asrar, Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Ajmal Ahmad, Alexandra De Zutter, Mohammad Mairaj Siddiquei, Marfa Blanter, Eef Allegaert, Priscilla W. Gikandi, Gert De Hertogh, Jo Van Damme, Ghislain Opdenakker, Sofie Struyf   +12 more
doaj   +1 more source

Effect of nanoparticles on the expression and activity of matrix metalloproteinases

Nanotechnology Reviews, 2018
Matrix metallopeptidases, commonly known as matrix metalloproteinases (MMPs), are a group of proteolytic enzymes whose main function is the remodeling of the extracellular matrix. Changes in the activity of these enzymes are observed in many pathological
Matysiak-Kucharek Magdalena, Czajka Magdalena, Sawicki Krzysztof, Kruszewski Marcin, Kapka-Skrzypczak Lucyna   +4 more
doaj   +1 more source

A Review of Toxins from Cnidaria

Marine Drugs, 2020
Cnidarians have been known since ancient times for the painful stings they induce to humans. The effects of the stings range from skin irritation to cardiotoxicity and can result in death of human beings.
Isabella D’Ambra, Chiara Lauritano
doaj   +1 more source

Metalloproteinases and Wound Healing [PDF]

Advances in Wound Care, 2015
Significance: Matrix metalloproteinases (MMPs) are present in both acute and chronic wounds. They play a pivotal role, with their inhibitors, in regulating extracellular matrix degradation and deposition that is essential for wound reepithelialization.
Matthew P, Caley, Vera L C, Martins, Edel A, O'Toole   +2 more
openaire   +2 more sources

Matrix Metalloproteinases and Glaucoma

Biomolecules, 2022
Matrix metalloproteinases (MMPs) are enzymes that decompose extracellular matrix (ECM) proteins. MMPs are thought to play important roles in cellular processes, such as cell proliferation, differentiation, angiogenesis, migration, apoptosis, and host defense.
Moo Hyun Kim, Su-Ho Lim
openaire   +3 more sources

Natural Flavones and Flavonols: Relationships among Antioxidant Activity, Glycation, and Metalloproteinase Inhibition

Cosmetics, 2020
Reactive oxygen and nitrogen species as well as advanced glycation endproducts (AGEs) and metalloproteinases (MMPs) play a key role in the development and progression of degenerative processes of body tissues, including skin.
Simone Ronsisvalle, Federica Panarello, Giusy Longhitano, Edy Angela Siciliano, Lucia Montenegro, Annamaria Panico   +5 more
doaj   +1 more source