Results 21 to 30 of about 125,457 (165)

Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity

Platelets, 2023
Platelet-specific collagen receptor glycoprotein (GP)VI is stable on the surface of circulating platelets but undergoes ectodomain cleavage on activated platelets.
Christine Shu Mei Lee, Amandeep Kaur, Samantha J. Montague, Sarah M. Hicks, Robert K. Andrews, Elizabeth E. Gardiner   +5 more
doaj   +1 more source

Genetic Determination of Bronchopulmonary Dysplasia Formation: Pros and Cons

Педиатрическая фармакология, 2017
Currently, researches are being actively carried out to identify genetic risk factors for the development of bronchopulmonary dysplasia (BPD) in premature infants, including genetic polymorphism encoding surfactants, matrix metalloproteinases, cytokines,
V. K. Pozharishchenskaya, I. V. Davydova, K. V. Savostianov, L. S. Namazova-Baranova, E. B. Pavlinova, A. V. Pushkov   +5 more
doaj   +1 more source

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases [PDF]

Circulation Research, 2003
Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the extracellular matrix. These proteinases play a central role in many biological processes, such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration.
Visse, R, Nagase, H
openaire   +2 more sources

Metalloproteinases as mediators of inflammation and the eyes: molecular genetic underpinnings governing ocular pathophysiology [PDF]

International Journal of Ophthalmology, 2017
There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases (MMPs); the Zn (2+)-dependent endoproteases in eye health along with ...
Mahavir Singh, Suresh C Tyagi
doaj   +1 more source

Metalloproteinases as biochemical markers of pregnancy pathology

Акушерство, гинекология и репродукция, 2022
The success in modern biology has significantly enriched scientific understanding of the pathogenetic basis underlying some diseases, including obstetric and gynecological practice.
K. N. Grigorieva, V. O. Bitsadze, J. Kh. Khizroeva, M. V. Tretyakova, D. V. Blinov, N. A. Makatsariya, V. I. Tsibizova, I. A. Nakaidze, N. R. Gashimova, E. Grandone, A. D. Makatsariya   +10 more
doaj   +1 more source

Zymography of Metalloproteinases

Current Protocols in Protein Science, 2003
AbstractZymography is an electrophoretic technique enabling visualization of the number and approximate size of peptidases in a sample on the basis of their hydrolysis of a protein substrate within the gel. The technique is particularly useful for analyzing the peptidase composition of complex biological samples because visualization depends directly ...
Troeberg, L, Nagase, H
openaire   +2 more sources

Evaluation of the Inhibition of other Metalloproteinases by Matrix Metalloproteinase Inhibitors [PDF]

Journal of Enzyme Inhibition, 1999
Two series of compounds synthesized as specific matrix metalloproteinase (MMP) inhibitors have been evaluated for their inhibition of non-MMPs. In a series of substituted succinyl hydroxamic acids, some were found to be significant (IC50 < 1 microM) inhibitors of leucine (microsomal) aminopeptidase, neprilysin (3.4.24.11), and thermolysin.
P A, Marcotte, I N, Elmore, Z, Guan, T J, Magoc, D H, Albert, D W, Morgand, M L, Curtin, R B, Garland, Y, Guo, H R, Heyman, J H, Holms, G S, Sheppard, D H, Steinman, C K, Wada, S K, Davidsen   +14 more
openaire   +2 more sources

The Role of Matrix Metalloproteinases in Thoracic Aortic Disease: Are They Indicators for the Pathogenesis of Dissections?

Biomedicines
The pathogenesis of aortic aneurysm and dissection continues to be under discussion. Extracellular matrix (ECM) remodeling processes in the aortic wall are hypothesized to be involved in the development of the disorders.
Marc Irqsusi, Lan Anh Dong, Fiona R. Rodepeter, Rabia Ramzan, Ildar Talipov, Tamer Ghazy, Madeline Günther, Sebastian Vogt, Ardawan J. Rastan   +8 more
doaj   +1 more source

Metalloproteinases as a prognostic factor for early postoperative period in patients with blunt splenic injuries

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2020
Objective: to evaluate the levels of metalloproteinases as a prognostic factor for early postoperative period in patients with blunt splenic injuries.Materials and methods. The study included 96 patients with blunt splenic injuries. Isolated lesions were
V. V. Maslyakov, S. E. Uryadov, V. R. Gorbelik, T. Ch. Allakhyarov, S. A. Kulikov, M. A. Shikhmagomedov, I. S. Aristova   +6 more
doaj  

Allelic and Genotypic Distribution of MMP13-77 A/G Polymorphism in Salvadoran Children With and Without Caries

Clinics and Practice
Background/Objectives: Polymorphisms in metalloproteinases (MMPs) have the potential to be probable genetic biomarkers of dental caries. The aim of this study was to evaluate the distribution of the MMP13 A/G rs2252070 single nucleotide polymorphism (SNP)
Wendy Escobar-González, Jorge Alegría-Torres, Yolanda Terán-Figueroa, Vianney Castañeda-Monroy, Aurelio Álvarez-Vargas, Carlo Eduardo Medina-Solís, Nuria Patiño-Marín   +6 more
doaj   +1 more source