Results 21 to 30 of about 218,326 (315)

Impact of Extracellular Matrix Components to Renal Cell Carcinoma Behavior

Frontiers in Oncology, 2020
Renal cell carcinoma (RCC) represents the main renal tumors and are highly metastatic. They are heterogeneous tumors and are subdivided in 12 different subtypes where clear cell RCC (ccRCC) represents the main subtype. Tumor extracellular matrix (ECM) is
Sandra Majo, Sandra Majo, Sarah Courtois, Wilfried Souleyreau, Wilfried Souleyreau, Andreas Bikfalvi, Andreas Bikfalvi, Patrick Auguste, Patrick Auguste   +8 more
doaj   +1 more source

Differential Expression of MMP2 and TIMP2 in Peripheral Blood Mononuclear Cells After Roux-en-Y Gastric Bypass

Frontiers in Nutrition, 2021
Matrix metalloproteinases (MMP) and their endogenous inhibitor, the tissue inhibitor of metalloproteinases (TIMP), are expressed in many different cell types and play an important role in physiologic and pathological degradation of extracellular matrix ...
Carla Barbosa Nonino, Natália Yumi Noronha, Maysa de Araújo Ferreira-Julio, Lígia Moriguchi Watanabe, Karen Francislaine Cassia, Carolina Ferreira Nicoletti, Caroline Rossi Welendorf, Wilson Salgado Junior, Dorotéia Rossi Silva Souza, Marcela Augusta de Souza Pinhel, Marcela Augusta de Souza Pinhel   +10 more
doaj   +1 more source

Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke. [PDF]

, 2016
Numerous studies have documented increases in matrix metalloproteinases (MMPs), specifically MMP-9 levels following stroke, with such perturbations associated with disruption of the blood brain barrier (BBB), increased risk of hemorrhagic complications ...
Adibhatla, Agrawal, Alcaide, Amantea, Amantea, Anthony, Asahi, Asahi, Asahi, Bajor, Bakowski, Bauer, Benarroch, Burk, Candelario-Jalil, Carbone, Castellanos, Castellanos, Chang, Chesler, Choi, Clark, Clark, Conant, Copin, Cuadrado, Cuadrado, Cunningham, Dejonckheere, Fanjul-Fernández, Fernandez-Patron, Ferry, Fiorelli, Frank R. Sharp, Fujimoto, Fujimura, Fujimura, Gasche, Gasche, Gasche, Gautier, Gidday, Golab, Gu, Gurney, Gürsoy-Ozdemir, Hacke, Harris, Heo, Heo, Horstmann, Hu, Inzitari, Jickling, Justicia, Keck, Kelly, Khandoga, Kim, Kuroiwa, Kurzepa, Lapchak, Lee, Lenglet, Lenglet, Li, Lucivero, Lukes, Lynch, Machado, Maier, Manabe, McCarthy, Moldes, Montaner, Montaner, Montaner, Montaner, Montaner, Montaner, Mun-Bryce, Murata, Nguyen, Ning, Oda, Opdenakker, Orbe, Piccardi, Planas, Ra, Ramos-Fernandez, Ranasinghe, Renée J. Turner, Reynolds, Rivera, Rodrigues, Rodríguez, Rodríguez-Yáñez, Romanic, Rosell, Rosell, Rosell, Rosenberg, Rosenberg, Rosenberg, Rosenberg, Sandoval, Schnoor, Shigemori, Si-Tayeb, Sotgiu, Steadman, Sternlicht, Sumii, Svedin, Tan, Tang, Tsuji, Tsuruoka, Turba, Van den Steen, Vandooren, Vukasovic, Wang, Wang, Wang, Yan, Yang, Yang, Yushchenko, Zhao, Zhao, Zhao, Zozulya   +133 more
core   +3 more sources

Extracellular Matrix Composition and Remodeling: Current Perspectives on Secondary Palate Formation, Cleft Lip/Palate, and Palatal Reconstruction

Frontiers in Cell and Developmental Biology, 2019
Craniofacial development comprises a complex process in humans in which failures or disturbances frequently lead to congenital anomalies. Cleft lip with/without palate (CL/P) is a common congenital anomaly that occurs due to variations in craniofacial ...
Katiúcia Batista Silva Paiva, Clara Soeiro Maas, Pâmella Monique dos Santos, José Mauro Granjeiro, José Mauro Granjeiro, Ariadne Letra, Ariadne Letra, Ariadne Letra   +7 more
doaj   +1 more source

Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis [PDF]

, 2005
Experimental autoimmune encephalomyelitis (EAE) is an animal model of inflammatory demyelination, a pathological event common to multiple sclerosis (MS). During CNS inflammation there are alterations in the extracellular matrix (ECM).
A.K. Cross, Abbaszzade, Asher, Bandtlow, Barrett, Behi, Brew, Cal, Collins-Racie, D.J. Buttle, G. Haddock, Hartung, Hashimoto, Hill, Inatani, J. Plumb, J. Surr, Jaworski, Kashiwagi, Kashiwagi, Krekoski, Kuno, Kuno, Kurazono, Langton, Lindberg, Lo, Lukes, M.N. Woodroofe, Matthews, Muir, Novak, Novak, Ohgoh, Pangalos, Porter, R.A.D. Bunning, Rosenberg, Sandy, Sasaki, Satoh, Sobel, Somerville, Tang, Teesalu, Toft-Hansen, Vankemmelbeke, Vankemmelbeke, Vazquez, Yamaguchi, Yu, Yuan, Zuo   +52 more
core   +1 more source

Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity

Platelets, 2023
Platelet-specific collagen receptor glycoprotein (GP)VI is stable on the surface of circulating platelets but undergoes ectodomain cleavage on activated platelets.
Christine Shu Mei Lee, Amandeep Kaur, Samantha J. Montague, Sarah M. Hicks, Robert K. Andrews, Elizabeth E. Gardiner   +5 more
doaj   +1 more source

Genetic Determination of Bronchopulmonary Dysplasia Formation: Pros and Cons

Педиатрическая фармакология, 2017
Currently, researches are being actively carried out to identify genetic risk factors for the development of bronchopulmonary dysplasia (BPD) in premature infants, including genetic polymorphism encoding surfactants, matrix metalloproteinases, cytokines,
V. K. Pozharishchenskaya, I. V. Davydova, K. V. Savostianov, L. S. Namazova-Baranova, E. B. Pavlinova, A. V. Pushkov   +5 more
doaj   +1 more source

Action of the Metalloproteinases in Gonadal Remodeling during Sex Reversal in the Sequential Hermaphroditism of the Teleostei Fish Synbranchus marmoratus (Synbranchiformes: Synbranchidae) [PDF]

, 2018
Teleostei present great plasticity regarding sex change. During sex reversal, the whole gonadincluding the germinal epithelium undergoes significant changes, remodeling, and neoformation.However, there is no information on the changes that occur within ...
Antoneli, Fernanda, Lo Nostro, Fabiana Laura, Mazzoni, Talita Sarah, Quagio-Grassiotto, Irani   +3 more
core   +2 more sources

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases [PDF]

Circulation Research, 2003
Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the extracellular matrix. These proteinases play a central role in many biological processes, such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration.
Visse, R, Nagase, H
openaire   +2 more sources

Metalloproteinases as mediators of inflammation and the eyes: molecular genetic underpinnings governing ocular pathophysiology [PDF]

International Journal of Ophthalmology, 2017
There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases (MMPs); the Zn (2+)-dependent endoproteases in eye health along with ...
Mahavir Singh, Suresh C Tyagi
doaj   +1 more source