Results 71 to 80 of about 331,204 (356)
The role of circular RNAs in regulating cytokine signaling in cancer
FEBS Open Bio, EarlyView.Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi +4 more
wiley +1 more source
Are matrix metalloproteinases the missing link? [PDF]
Invertebrate Survival Journal, 2005 It is more and more evident that the matrix metalloproteinase (MMP) system is not a characteristic feature of vertebrate animals only, as it can also be found in many invertebrate organisms.
F Mannello, G Tonti, S Papa
doaj +1 more source
Acta Biomedica Scientifica, 2012 Matrix metalloproteinases are main proteolytic enzymes breaking down most components of extracellular matrix of various tissues. In the review shows role of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases during implantation,
Yu. V. Korenovsky +6 more
doaj
Multifaceted role of Matrix Metalloproteinases (MMPs)
Frontiers in Molecular Biosciences, 2015 Matrix metalloproteinases (MMPs), a large family of calcium-dependent zinc-containing endopeptidases, are involved the tissue remodeling and degradation of the extracellular matrix.
Divya eSingh +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley +1 more source
Matrix metalloproteinases in skin [PDF]
Experimental Dermatology, 1997 Abstract Matrix metalloproteinases (MMPs) are a family of zinc‐dependent endopeptidases collectively capable of degrading essentially all extracellular matrix components. These enzymes can be produced by several different types of cells in skin such as fibroblasts, keratinocytes.
Veli-Matti Kähäri, Ulpu Saarialho-Kere
openaire +3 more sources
Basic fibroblast growth factor mediates carotid plaque instability through metalloproteinase-2 and –9 expression [PDF]
, 2004 OBJECTIVE(S): We hypothesized that basic fibroblast growth factor (bFGF) may exert a role in carotid plaque instability by regulating the expression of matrix metalloproteinases (MMP).
CAVALLARO, Antonino +6 more
core +1 more source
Glycosylation Gene Signatures as Prognostic Biomarkers in Glioblastoma
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioblastoma (GBM) is an aggressive brain tumor characterized by significant heterogeneity. This study investigates the role of glycosylation‐related genes in GBM subtyping, prognosis, and response to therapy. Methods We analyzed mRNA expression data and clinical information from The Cancer Genome Atlas (TCGA) and Gene Expression ...
Tong Zhao +4 more
wiley +1 more source
Matrix metalloproteinases and atherosclerosis
Postępy Higieny i Medycyny Doświadczalnej, 2011 Matrix metalloproteinases (MMPs), a family of proteolytic enzymes that degrade extracellular matrix (ECM), seem to have an important role in pathogenesis of atherosclerosis. Released by inflammatory cells and smooth muscle cells, MMPs regulate the vascular remodeling process.
Piotr Fic +3 more
openaire +3 more sources
Matrix metalloproteinases in emphysema [PDF]
Matrix Biology, 2018 Several studies have implicated a causative role for specific matrix metalloproteinases (MMPs) in the development and progression of cigarette smoke-induced chronic obstructive pulmonary disease (COPD) and its severe sequela, emphysema. However, the precise function of any given MMP in emphysema remains an unanswered question.
Anne M. Manicone +2 more
openaire +2 more sources