Results 101 to 110 of about 1,153,013 (262)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Project-matrix models of marketing organization [PDF]
Marketing (Beograd. 1991), 2009 Unlike theory and practice of corporation organization, in marketing organization numerous forms and contents at its disposal are not reached until this day.
Gutić Dragutin, Rudelj Siniša
doaj
Demography_Lab, an educational application to evaluate population growth: Unstructured and matrix models. [PDF]
Ecol Evol, 2021 Arrontes J.
europepmc +1 more source
Modern Physics Letters A, 1993 We show that an integral transform of the fluctuations of the collective field of the d=1 matrix model satisfy the same linearized equation as that of the massless “tachyon” in the black hole background of the two-dimensional critical string. This suggests that the d=1 matrix model may provide a non-perturbative description of black holes in two ...
openaire +2 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Bubbling wormholes and matrix models
Journal of High Energy PhysicsThe thermofield double state entangles two copies of a CFT via a sum over energy eigenstates and is dual to the two-sided eternal black hole. We explore an analogous construction using sums over gauge group representations of half-BPS Wilson loops in ...
Panos Betzios +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
W-representations for multi-character partition functions and their β-deformations
Physics Letters BIn this letter we continue the development of W-representations. We propose several generalizations of the known models, such as the hypergeometric Hurwitz τ-functions.
Lu-Yao Wang +4 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source