Results 111 to 120 of about 2,534,683 (266)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Matrix product state on a quantum computer

New Journal of Physics
Solving quantum many-body systems is one of the most significant regimes where quantum computing applies. Currently, as a hardware-friendly computational paradigms, variational algorithms are often used for finding the ground energy of quantum many-body ...
Yong Liu, Guangyao Huang, Yizhi Wang, Junjie Wu   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Site basis excitation Ansatz for matrix product states

SciPost Physics Core
We introduce a simple and efficient variation of the tangent-space excitation Ansatz used to compute elementary excitation spectra of one-dimensional quantum lattice systems using matrix product states (MPS).
Steven R. White
doaj   +1 more source

The associations between dietary practices and dietary quality, biological health indicators, perceived stress, religiosity, culture, and gender in multicultural Singapore

Journal of Ethnic Foods, 2018
Background: Dietary quality, biological health, culture, religiosity, and perceived stress are co-related. However, there is a dearth of research conducted on Asian populations in secularized and harmonious multicultural societies.
Rachel Yi-Xin Ng, Yi-Sheng Wong, Joshua-Yi Yeo, Crystal Ling-Zhen Koh, Cynthia Wilson, Samuel Ken-En Gan   +5 more
doaj   +1 more source

Fast mutual exclusivity algorithm nominates potential synthetic lethal gene pairs through brute force matrix product computations. [PDF]

Comput Struct Biotechnol J, 2021
Fedrizzi T, Ciani Y, Lorenzin F, Cantore T, Gasperini P, Demichelis F.   +5 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Continuous matrix-product operators for quantum fields

Physical Review Research
In this work, we introduce an ansatz for continuous matrix-product operators for quantum field theory. We show that (1) they admit a closed-form expression in terms of finite number of matrix-valued functions without reference to any lattice parameter ...
Erickson Tjoa, J. Ignacio Cirac
doaj   +1 more source

Hybrid Stabilizer Matrix Product Operator

Physical Review Letters
7 pages, 5 ...
Mello, Antonio Francesco, Santini, Alessandro, Collura, Mario   +2 more
openaire   +4 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source