Results 61 to 70 of about 21,996,514 (252)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Force parameters of metal deformation during sheet drawing
Structural Mechanics of Engineering Constructions and Buildings, 2020 The aim of the work. The effect of the curvature of the rounding of torus surfaces during the formation of a cylindrical product (glass) is investigated, taking into account the plastic thinning of the deformable material at the end edges of the matrix ...
Yury A. Morozov
doaj +1 more source
Infinite boundary conditions for matrix product state calculations [PDF]
, 2012 We propose a formalism to study dynamical properties of a quantum many-body system in the thermodynamic limit by studying a finite system with "infinite boundary conditions" where both finite-size effects and boundary effects have been eliminated.
Vidal, Guifre +2 more
core +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
An accurate Lanczos method for the matrix product state representation
Communications PhysicsThe Lanczos algorithm naturally finds multiple low-lying eigenstates simultaneously, providing a global and robust treatment of the spectrum without local minima or root flipping.
Yu Wang +3 more
doaj +1 more source
Quantum Subroutine for Efficient Matrix Multiplication
IEEE AccessWe propose an efficient quantum subroutine for matrix multiplication that computes a state vector encoding the entries of the product of two matrices in superposition.
Anna Bernasconi +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Quantum phase estimation with optimal confidence interval using three control qubits [PDF]
QuantumQuantum phase estimation is an important routine in many quantum algorithms, particularly for estimating the ground state energy in quantum chemistry simulations. This estimation involves applying powers of a unitary to the ground state, controlled by an
Kaur Kristjuhan, Dominic W. Berry
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source