Advanced Healthcare Materials, EarlyView.Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină +2 more
wiley +1 more source
Plasmonic Enhancement of Fluorescence and Protein Dynamics in Living Mammalian Cells
Advanced Materials, EarlyView.This study demonstrates plasmonic enhancement of the function of fluorescent voltage sensing proteins (genetically encoded voltage indicators, (GEVIs), QuasAr6) in live mammalian cells. Coupling to plasmonic nanoparticles does not just increase fluorescence, but influences the protein photocycle, creating a hybrid sensor with its response speed to ...
Marco Locarno +16 more
wiley +1 more source
Matrix Stiffness Regulates the Osteogenic Differentiation of hPDLSCs via DNA Methylation. [PDF]
Int Dent JDing R +8 more
europepmc +1 more source
Rapid Fabrication of Self‐Propelled and Steerable Magnetic Microcatheters for Precision Medicine
Advanced Materials, EarlyView.A rapid Joule heating fabrication method for the production of self‐propelling, adaptive microcatheters, with tunable stiffness and integrated microfluidic channels is presented. Demonstrated through three microrobotic designs, including a steerable guiding catheter, an untethered wave‐crawling TubeBot, and a distal‐end propelled microcatheter, it was ...
Zhi Chen +5 more
wiley +1 more source
Matrix Stiffness Regulates TGFβ1-Induced αSMA Expression via a G9a-LATS-YAP Signaling Cascade. [PDF]
FASEB BioadvSankhe CS +11 more
europepmc +1 more source
Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives
Advanced Materials, EarlyView.Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi +4 more
wiley +1 more source
A matrix stiffness gene signature identifies SLC20A1 as a novel mechano-immunological checkpoint enabling synergistic immunotherapy in pancreatic ductal adenocarcinoma. [PDF]
Cancer Immunol ImmunotherZhao C, Lu Y, He L, Zhang Y, Yin T.
europepmc +1 more source
Intelligent Acousto‐Electrical Metamaterials (IAM) for Sound Source Detection
Advanced Materials, EarlyView.Our proposed metamaterial concept enables sound source detection using a single material, in contrast to conventional arrays that require dozens or even hundreds of transducers. We show that the coupled acoustic–vibrational–electrical responses in piezoelectric metamaterials give rise to topology‐governed charge transport, producing distinct voltage ...
Victor Couëdel +7 more
wiley +1 more source
High matrix stiffness triggers the YAP-OPA1-TET1/3 loop to drive chemoresistance via enhanced nuclear-mitochondrial communication. [PDF]
iScienceWu P +11 more
europepmc +1 more source
Mechanically Programmable DNA Hydrogel Microparticles for 3D Cellular Systems
Advanced Materials, EarlyView.DNA hydrogel microparticles are designed to exhibit controllable viscoelasticity and stiffness across three orders of magnitude from 30Pa$30 \,\mathrm{Pa}$ to 6.5kPa$6.5 \,\mathrm{kPa}$. They are uptaken into fibroblast spheroids where they are actively remodeled by cellular forces depending on their mechanical properties.
Tobias Walther +9 more
wiley +1 more source