Results 61 to 70 of about 3,705,438 (306)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Matrix Transformations of Double Convergent Sequences with Powers for the Pringsheim Convergence

open access: yesMathematics
In 2004–2006, the corresponding double sequence spaces were defined for the Pringsheim and the bounded Pringsheim convergence by Gokhan and Colak. In 2009, Colak and Mursaleen characterized some classes of matrix transformations transforming the space of
Maria Zeltser, Şeyda Sezgek
doaj   +1 more source

Transforming a Matrix into a Standard Form

open access: yesInterdisciplinary Information Sciences, 2017
6 pages, minor ...
MUNEMASA, Akihiro, PUTRI, Pritta Etriana
openaire   +4 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Matrix Transformations of Generalized Almost Convergent Double Sequences

open access: yesAxioms
In this paper, we study matrix transformations on spaces of generalized almost convergent double sequences with powers. Extending classical results of Lorentz, Maddox, and Nanda, we characterize several classes of infinite matrices that map between ...
Maria Zeltser, Ekrem Savas
doaj   +1 more source

The coordinate system transformation of a serial kinematic structures and use in the derivation of systems motion equations

open access: yesMATEC Web of Conferences, 2016
This text discusses the use of transformation matrices to determine the motion equations of the complex mechanical structure. Use of the transformation matrix does not apply only to motion equations but has the general use in relative positions determine
Zátopek Jiří
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

open access: yesFEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual   +3 more
wiley   +1 more source

Analysis of the algorythms accuracy of the plane and space geodetic coordinates transformation

open access: yesGeodesy and Cartography, 2012
The accuracy of the coordinates computed by transformation from one system to another is analysed. Values of transformation parameters are computed by the least-square method taking into account the accuracy of the coordinates of the identical points in ...
Jonas Skeivalas, Robertas Dargis
doaj   +1 more source

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