Results 91 to 100 of about 628,164 (291)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Applications of Measure of Noncompactness in Matrix Operators on Some Sequence Spaces

Abstract and Applied Analysis, 2012
We determine the conditions for some matrix transformations from n(ϕ), where the sequence space n(ϕ), which is related to the ℓp spaces, was introduced by Sargent (1960).
M. Mursaleen, A. Latif
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Comparison of transformations with inhomogeneous nucleation and transformations with inhomogeneous growth velocity

Journal of Materials Research and Technology, 2019
In this paper, we carry out computer simulations of transformations to compare two distinct situations regarding nucleation and growth. The first situation is that in which the nucleation is not homogeneous in space: the nuclei are located ...
Mariana Sizenando Lyrio, André Luiz Moraes Alves, Gabriella Maria Silveira de Sá, Harison da Silva Ventura, Weslley Luiz da Silva Assis, Paulo Rangel Rios   +5 more
doaj   +1 more source

Explicit Evaluations of Matrix-variate Gamma and Beta Integrals in the Real and Complex Cases [PDF]

, 2014
Matrix transformations in terms of triangular matrices is the easiest method of evaluating matrix-variate gamma and beta integrals in the real and complex cases.
Mathai, A. M.
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A new series space |N_{p}^{θ}|(μ) and matrix operators with applications

Kuwait Journal of Science, 2018
The space |N_{p}^{θ}|_{k} of all series summable absolute weighted mean method has recently been introduced and studied by (Sarıgöl 2011), (Sarıgöl 2016) and (Mohapatra and Sarıgöl).
Fadime Gökçe, Mehmet A. Sarıgöl
doaj  

Paranormed spaces of absolute tribonacci summable series and some matrix transformations

Dera Natung Government College Research Journal
In a more recent paper, the absolute series space I T_\Phi I_q   which is defined as the domain of the matrix corresponding to the absolute Tribonacci summability in the well-known space l_q has taken place in the literature (Gökçe, in press).
Fadime Gökçe
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source