Results 101 to 110 of about 1,708,170 (337)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Projecting health-care expenditure for Switzerland: further evidence against the 'red-herring' hypothesis [PDF]
This paper contributes to the debate about the impact of population ageing on health care expenditure. Some health economists claim that the commonly presumed impact of population ageing is a "red herring".
Colombier, Carsten, Weber, Werner
core +1 more source
Deadly Predators and Virtuous Buddhists: Dog Population Control and the Politics of Ethics in Ladakh [PDF]
, 2019 The region of Ladakh in the Indian Himalayas has recently seen a rise in attacks by stray dogs, some of which have been fatal. The dogs’ claims on territory have not gone uncontested in an emotional landscape fraught with anxieties over religious ...
Gagné, Karine
core +1 more source
Economic evaluation: what does a nurse manager need to know?
, 2005 This paper considers how health economists can assist nurse managers, using the concepts and tools of economic evaluation. We aim to clarify these and also explode some of the myths about economic evaluation and its role in health care decision-making ...
Douglas, Hannah-Rose, Normand, Charles
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
BJOG: an International Journal of Obstetrics and Gynaecology, 2016 Global uptake of antenatal care (ANC) varies widely and is influenced by the value women place on the service they receive. Identifying outcomes that matter to pregnant women could inform service design and improve uptake and effectiveness.
S. Downe +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Rural workers have less access to paid sick days [PDF]
, 2011 This brief, using data from the 2008 National Study of the Changing Workforce (NSCW) survey, analyzes paid sick time rates of workers by place and type of work. Paid sick days provide job protection to workers and a steady paycheck when they need to care
Schaefer, Andrew P., Smith, Kristin
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source