Results 331 to 340 of about 1,879,090 (387)

Options for Final Oocyte Maturation Trigger: Can the Ovarian Response Prediction Index (ORPI) Guide the Optimal Choice? [PDF]

JBRA Assist Reprod
Franco Junior JG, Petersen CG, Meziara JB, Oliveira JBA.   +3 more
europepmc   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

An emerging clock mechanism in a hydrozoan jellyfish. [PDF]

PLoS Biol
Rosato E.
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

New Classification of Midpalatine Suture Maturation Using Cone Beam Computed Tomographic Study. [PDF]

Diagnostics (Basel)
Soman C, Alshammari RK, AlMutairi NM, Alenezi LM, Alaadwany R, Baseer MA, Aldahash F, AlOsaimi M, Ahmed ST, Ajwa N, Ahmed YT.   +10 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Mitochondrial Metabolic Checkpoints in Human Fertility: Reactive Oxygen Species as Gatekeepers of Gamete Competence. [PDF]

Cells
Stavros S, Thomakos N, Moustakli E, Daponte N, Sioutis D, Kathopoulis N, Zikopoulos A, Anagnostaki I, Christodoulaki C, Grigoriadis T, Domali E, Potiris A.   +11 more
europepmc   +1 more source

Effects of Dietary Tryptophan Supplementation on Melatonin and Oocyte Maturation in African Catfish, Clarias Gariepinus

Epro Barades, Iskandar Iskandar, Ibnu Dwi Buwono, Ibnu Dwi Buwono, Yuli Andriani, Ayi Yustiati, Roffi Grandiosa, Ratu Siti Aliah   +7 more
openalex   +1 more source

Comparative β-cell development: insights from Rodents, humans and induced pluripotent stem cell models. [PDF]

Stem Cell Res Ther
Darwish R, Alcibahy Y, Nandakumar M, Butler AE, Moin ASM.   +4 more
europepmc   +1 more source

Convolutional neural network-derived neurofibrillary tangle classifiers: Investigative tools to identify maturation levels and explore post-translational modifications using laser capture microdissection coupled mass spectrometry. [PDF]

J Neuropathol Exp Neurol
Jimenez Jaramillo C, Nedderman D, Ahat E, McElwee JL, Soper M, Ballard D, Zhang L, Credille KM, Heady G, Hsi ED, Hodsdon ME, Holzer TR, Gruver AM, Harrison WT.   +13 more
europepmc   +1 more source