Results 41 to 50 of about 895,186 (317)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen   +23 more
wiley   +1 more source

The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCs) - Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2

open access: yes, 2001
Toll-like receptors (TLRs) have been found to be key elements in pathogen recognition by the host immune system. Dendritic cells (DCs) are crucial for both innate immune responses and initiation of acquired immunity.
Dimmeler, S   +20 more
core   +1 more source

Seasonal variation of immune response to heterologous erythrocytes in natural populations of red‐backed (Clethrionomys rutilus) and gray‐sided (C. rufocanus) voles in Western Siberia

open access: yesEcology and Evolution, 2022
We studied the seasonal variation of adaptive humoral immunity (AHI) in northern red‐backed vole (Clethrionomys rutilus Pallas, 1779, RBV) and gray‐sided vole (C. rufocanus Sundevall, 1846, GSV) in Tomsk region of Western Siberia.
Larisa B. Kravchenko   +1 more
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu   +8 more
wiley   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker   +11 more
wiley   +1 more source

The maturation of reticulocytes. I. Following introduction of reticulocytes into polycythemic and normocythemic animals

open access: yes, 1975
Investigations were conducted on the life-span of "stress" reticulocytes and the fate of the early denucleated large-sized reticulocytes in circulating blood.
Shimada, Atsuko
core   +1 more source

Tracking the chemical composition of 3D printed 94 % alumina during the thermal post-process

open access: yesAdditive Manufacturing Letters
Additive manufactured (AM) 94 % alumina was successfully 3D printed using the Lithography Ceramic Manufacturing (LCM) technique. Each 3D printed sample was exposed to a different stage of the thermal post-process to identify changes in chemical ...
Sofia G Gomez   +5 more
doaj   +1 more source

Engineering the Vasculature of Stem-Cell-Derived Liver Organoids

open access: yesBiomolecules, 2021
The vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids with a vascular network offer great application prospects for drug screening, disease modeling, and ...
Xv Zhang, Liling Tang, Qian Yi
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke   +4 more
wiley   +1 more source

P53 Activation Promotes Maturational Characteristics of Pluripotent Stem Cell‐Derived Cardiomyocytes in 3‐Dimensional Suspension Culture Via FOXO‐FOXM1 Regulation

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Current protocols generate highly pure human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs) in vitro that recapitulate characteristics of mature in vivo cardiomyocytes.
Nivedhitha Velayutham   +21 more
doaj   +1 more source

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