Results 41 to 50 of about 8,466 (229)
Lattice rules of minimal and maximal rank with good figures of merit
Journal of Computational and Applied Mathematics, 1999 The error of numerical cubature of periodic functions in \(s\) dimensions by lattice rules can be estimated in terms of the so-called figure of merit \(\rho\). The problem of finding good rules having \(N\) distinct nodes can therefore conveniently be reduced to that of finding rules with large values of \(\rho\).
openaire +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Reconstruction of the Ranks of the Nonextremal Cards and of Ordered Sets with a Minmax Pair of Pseudo-Similar Points [PDF]
For every ordered set, we reconstruct the deck obtained by removal of the elements of rank r that are neither minimal nor maximal. Consequently, we also reconstruct the deck obtained by removal of the extremal, that is, minimal or maximal, elements ...
Schröder, Bernd S. W.
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
, 2012 In this thesis we consider in detail the following two fundamental problems for semigroup presentations: 1. Given a semigroup find a presentation defining it. 2. Given a presentation describe the semigroup defined by it.
Ruškuc, Nik
core +2 more sources
Decision Science Letters, 2019 This paper proposes a new method on ranking fuzzy numbers through the process of defuzzification by using maximizing and minimizing set on the triangular fuzzy numbers formed from generalized trapezoidal fuzzy numbers. In this method, a total utility value of each fuzzy number is defined by considering two left and two right utility values along with ...
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FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source