Results 31 to 40 of about 133,193 (234)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

eLife
Large transcellular pores elicited by bacterial mono-ADP-ribosyltransferase (mART) exotoxins inhibiting the small RhoA GTPase compromise the endothelial barrier.
Camille Morel, Eline Lemerle, Feng-Ching Tsai, Thomas Obadia, Nishit Srivastava, Maud Marechal, Audrey Salles, Marvin Albert, Caroline Stefani, Yvonne Benito, François Vandenesch, Christophe Lamaze, Stéphane Vassilopoulos, Matthieu Piel, Patricia Bassereau, David Gonzalez-Rodriguez, Cecile Leduc, Emmanuel Lemichez   +17 more
doaj   +1 more source

Numerical modeling of the equatorial electrojet UT-variation on the basis of the model GSM TIP [PDF]

Advances in Radio Science, 2007
In the presented work the results of numerical modeling of the UT-variation of the equatorial electrojet, executed on the basis of the model GSM TIP are presented, taking into account the dynamo electric fields generated by thermospheric winds in a ...
M. V. Klimenko, V. V. Klimenko, V. V. Bryukhanov   +2 more
doaj  

Information Entropy and Information Granulation-based Uncertainty Measures in Incomplete Information Systems [PDF]

, 2014
: In this paper, concepts of information entropy and information granulation-based uncertainty measures are introduced in incomplete information/decision systems, and based on maximal consistent block technique, some variants of information entropy and ...
Xu, Jiucheng, Tianhe Xu, Lin Sun, Sun, Lin, Xu, Tianhe, Jiucheng Xu   +5 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Expanding the boundaries: investigating the integration of contextual information across a spectrum of inter-trial variability

Frontiers in Psychology
It is well-documented that feature integration across perception and action creates a retrievable episodic representation, known as a stimulus-response episode or an event file.
Ruyi Qiu, Yanzhi Mo
doaj   +1 more source

Regulate the Stability of Gyroids of ABC-Type Multiblock Copolymers by Controlling the Packing Frustration

, 2020
We propose to regulate the stability of gyroids of ABC-type multiblock copolymers by controlling the packing frustration of majority-component B-blocks.
Weihua Li (144468), Qiong Xie, Weihua Li, Qiong Xie (709001), Yicheng Qiang (3187944), Yicheng Qiang   +5 more
core   +1 more source