Results 41 to 50 of about 133,193 (234)

Atrial-ventricular differences in rabbit cardiac voltage-gated Na⁺ currents:basis for atrial-selective block by ranolazine [PDF]

, 2017
BACKGROUND Class 1 antiarrhythmic drugs are highly effective in restoring and maintaining sinus rhythm in atrial fibrillation patients but carry a risk of ventricular tachyarrhythmia.
Hancox, Jules, James, A.F., Rachel E. Caves, Simon M. Bryant, Caves, R.E., Jules C. Hancox, Hanne C. Gadeberg, Stéphanie C. Choisy, Bryant, Simon, James, Andrew, Cheng, Hongwei, Bryant, S.M., Hancox, J.C., Hongwei Cheng, Gadeberg, Hanne, Choisy, S.C., Choisy, Stephanie, Andrew F. James, Cheng, H., Gadeberg, H.C., Caves, Rachel   +20 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

GABAA receptor agonists modulate intracellular Ca2+ levels in activated human CD4+ T cells

Frontiers in Immunology
GABA binding to GABAA receptors induces transient elevation in intracellular Ca2+ concentrations in activated human CD4+ T cells. Here we examined the Ca2+ response evoked by the GABAA receptor agonists THIP, muscimol, isoguvacine, and TACA and further ...
Sergiy V. Korol, Zhe Jin, Amol K. Bhandage, Hayma Hammoud, Bryndis Birnir   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Estimation of temporal parameters during sprint running using a trunk-mounted inertial measurement unit [PDF]

, 2012
This research was supported by a grant of the Universit a Italo-Francese (Call Vinci) awarded to E. Bergamini.The purpose of this study was to identify consistent features in the signals supplied by a single inertial measurement unit (IMU), or thereof ...
PICERNO, Pietro, NATTA, Françoise, CAMOMILLA, Valentina, THOREUX, Patricia, PILLET, Helene, BERGAMINI, Elena   +5 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Effects of progressive versus consistent dose of caffeine ingestion on volleyball players’ exercise performance adaptations following plyometric jump training

Frontiers in Nutrition
BackgroundThe consumption of caffeine (CAF) to enhance adaptations in athletes has been documented in prior studies; however, the identification of an optimal approach for CAF supplementation during short-term interventions remains unclear.
Ganfang Zhu, Keqi Fu, Yangzheng Xie
doaj   +1 more source

DYNAMICS OF ENTANGLEMENT IN HEISENBERG CHAINS WITH ASYMMETRIC DZYALOSHINSKII–MORIYA INTERACTIONS

, 2011
Dynamics of the nearest-neighbor concurrence and the block–block entanglement in closed Heisenberg chains with Dzyaloshinskii–Moriya (DM) interactions are simulated numerically.
J. REN, Y. Z. WU, X. F. JIANG
core   +1 more source