Results 41 to 50 of about 492,566 (255)

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi   +5 more
wiley   +1 more source

Subconductance block of single mechanosensitive ion channels in skeletal muscle fibers by aminoglycoside antibiotics

open access: yesThe Journal of General Physiology, 1996
The activity of single mechanosensitive channels was recorded from cell- attached patches on acutely isolated skeletal muscle fibers from the mouse.
B. Winegar, Christine M Haws, B. Lansman
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

See-saw Mechanisms for Dirac and Majorana Neutrino Masses [PDF]

open access: yes, 2001
We investigate the see-saw mechanism for generally non-fine-tuned $n \times n$ mass matrices involving both Dirac and Majorana neutrinos. We specifically show that the number of naturally light neutrinos cannot exceed half of the dimension of the ...
Lindner, Manfred   +2 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

T cell recognition of nonpolymorphic determinants on H-2 class I molecules. [PDF]

open access: yes, 1988
Recognition of polymorphic determinants on class I or class II MHC Ag is required for T lymphocyte responses. Using cell-size artificial membranes (pseudocytes) bearing H-2 class I Ag it is demonstrated that T cells can, in addition, recognize ...
Goldstein, SA, Mescher, MF
core  

Predicting trend reversals using market instantaneous state

open access: yes, 2014
Collective behaviours taking place in financial markets reveal strongly correlated states especially during a crisis period. A natural hypothesis is that trend reversals are also driven by mutual influences between the different stock exchanges.
Bury, Thomas
core   +1 more source

The Minimum Consistent Spanning Subset Problem on Trees

open access: yesJ. Graph Algorithms Appl.
Given a vertex-colored edge-weighted graph, the minimum consistent subset (MCS) problem asks for a minimum subset $S$ of vertices such that every vertex $v\notin S$ has the same color as its nearest neighbor in $S$. This problem is NP-complete.
Ahmad Biniaz, Parham Khamsepour
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

open access: yeseLife
Large transcellular pores elicited by bacterial mono-ADP-ribosyltransferase (mART) exotoxins inhibiting the small RhoA GTPase compromise the endothelial barrier.
Camille Morel   +17 more
doaj   +1 more source

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