Results 111 to 120 of about 134,540 (296)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Fixed Point Theory and Applications, 2009 We introduce an iterative scheme for finding a common element of the solution set of a maximal monotone operator and the solution set of the variational inequality problem for an inverse strongly-monotone operator in a uniformly smooth and uniformly ...
Somyot Plubtieng, Wanna Sriprad
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Generalized vector quasi-variational-like inequalities
Journal of Inequalities and Applications, 2006 Using maximal element theorem, we prove some existence theorems for the two types of generalized vector quasi-variational-like inequalities with non-monotonicity and non-compactness.
Peng Jian-Wen, Yang Xin-Min
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Modeling of MOEMS electromagnetic scanning grating mirror for NIR micro-spectrometer
AIP Advances, 2016 In this paper, the mathematical model is developed for researching the detailed electromagnetic mechanism of MOEMS scanning mirror. We present the relationship between spectral range and optical scanning angle.
Ying Zhou +3 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
ON COMMUTATIVE GELFAND RINGS [PDF]
Journal of Sciences, Islamic Republic of Iran, 1999 A ring is called a Gelfand ring (pm ring ) if each prime ideal is contained in a unique maximal ideal. For a Gelfand ring R with Jacobson radical zero, we show that the following are equivalent: (1) R is Artinian; (2) R is Noetherian; (3) R has a finite ...
doaj
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Spectral Space of H-Fuzzy Prime Ideals in Distributive Join-Semilattices
Journal of Applied MathematicsThe essential characteristics of H-fuzzy prime ideals and H-fuzzy maximal ideals within distributive join-semilattices are introduced and examined in this work.
Mohammed Amare Mohammed +3 more
doaj +1 more source