Results 101 to 110 of about 177,831 (292)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Maximal coherence and the resource theory of purity

open access: yesNew Journal of Physics, 2018
The resource theory of quantum coherence studies the off-diagonal elements of a density matrix in a distinguished basis, whereas the resource theory of purity studies all deviations from the maximally mixed state. We establish a direct connection between
Alexander Streltsov   +4 more
doaj   +1 more source

Maximal entries of elements in certain matrix monoids

open access: yes, 2017
Let $L_u=\begin{bmatrix}1 & 0\\u & 1\end{bmatrix}$ and $R_v=\begin{bmatrix}1 & v\\0 & 1\end{bmatrix}$ be matrices in $SL_2(\mathbb Z)$ with $u, v\geq 1$. Since the monoid generated by $L_u$ and $R_v$ is free, we can associate a depth to each element based on its product representation.
Han, Sandie   +3 more
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Доступ к полному тексту открыт О НОСИТЕЛЯХ МАКСИМАЛЬНЫХ СЦЕПЛЕННЫХ СИСТЕМ

open access: yesПроблемы анализа, 2004
This article is devoted to the functor of superextension. By definition, the superextansion of a compact space consist of all maximal linked systems of that space.
ВАКУЛОВА Е.В.
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Representation of certain classes of distributive lattices by sections of sheaves

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1980
Epstein and Horn ([6]) proved that a Post algebra is always a P-algebra and in a P-algebra, prime ideals lie in disjoint maximal chains. In this paper it is shown that a P-algebra L is a Post algebra of order n≥2, if the prime ideals of L lie in disjoint
U. Maddana Swamy, P. Manikyamba
doaj   +1 more source

A selection of maximal elements under non-transitive indifferences

open access: yes
In this work we are concerned with maximality issues under intransitivity of the indifference. Our approach relies on the analysis of "undominated maximals" (cf., Peris and Subiza, J Math Psychology 2002).
Alcantud, José Carlos R.   +2 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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