Results 101 to 110 of about 14,117,029 (318)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Quantitative description of upper extremity function and activity of people with spinal muscular atrophy

Journal of NeuroEngineering and Rehabilitation, 2020
Background Therapeutic management of the upper extremity (UE) function of people with spinal muscular atrophy (SMA) requires sensitive and objective assessment.
Mariska M. H. P. Janssen, Laura H. C. Peeters, Imelda J. M. de Groot   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Boundedness of the Hardy-Littlewood Maximal Operator and Multilinear Maximal Operator in Weighted Morrey Type Spaces

Journal of Function Spaces, 2014
The aim of this paper is to prove the boundedness of the Hardy-Littlewood maximal operator on weighted Morrey spaces and multilinear maximal operator on multiple weighted Morrey spaces. In particular, the result includes the Komori-Shirai theorem and the
Takeshi Iida
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Bloom-type two-weight inequalities for commutators of maximal functions

Analysis and Geometry in Metric Spaces
We study Bloom-type two-weight inequalities for commutators of the Hardy-Littlewood maximal function and sharp maximal function. Some necessary and sufficient conditions are given to characterize the two-weight inequalities for such commutators.
Zhang Pu, Fan Di
doaj   +1 more source

Hölder Quasicontinuity in Variable Exponent Sobolev Spaces

Journal of Inequalities and Applications, 2007
We show that a function in the variable exponent Sobolev spaces coincides with a Hölder continuous Sobolev function outside a small exceptional set.
Katja Tuhkanen, Juha Kinnunen, Petteri Harjulehto   +2 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Matrix weights and a maximal function with exponent 3/2

Advanced Nonlinear Studies
We build an example of a simple sparse operator for which its norm with scalar A 2 weight has linear estimate in [w]A2 ${\left[w\right]}_{{A}_{2}}$ , but whose norm in matrix setting grows at least as [W]A23/2 ${\left[W\right]}_{{\mathbf{A}}_{2}}^{3/2}$
Treil Sergei, Volberg Alexander
doaj   +1 more source

Vector-Valued Inequalities in the Morrey Type Spaces

International Journal of Mathematics and Mathematical Sciences, 2014
We will obtain the strong type and weak type estimates for vector-valued analogues of classical Hardy-Littlewood maximal function, weighted maximal function, and singular integral operators in the weighted Morrey spaces Lp,κ(w) when 1 ...
Hua Wang
doaj   +1 more source