Results 111 to 120 of about 6,122,747 (284)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Modeling longitudinal changes in maximal-intensity exercise performance in young male rowing athletes. [PDF]

, 2012
The purpose of the current study was to examine the effect of age and body size upon maximal-intensity exercise performance in young rowing athletes. Male participants (n = 171) aged 12-18 years were assessed using an "all-out" 30-s rowing ergometer test,
Markovic, Goran, Blazina, Tomislav, Mikulic, Pavle, Nevill, Alan M.   +3 more
core   +1 more source

The Pulmonary Function and Respiratory Muscle Strength in Thai Obese Children

Siriraj Medical Journal, 2007
Objective: This study was to compare the pulmonary function, respiratory muscle strength, and physical activity level between obese and non-obese children and to determine the correlation between pulmonary function, respiratory muscle strength and ...
Noppawan Charususin, Suwannee Jarungjitaree, Pipop Jirapinyo, Saipin Prasertsukdee   +3 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Commutators of fractional maximal functions with Lipschitz functions on mixed-norm amalgam spaces

Results in Applied Mathematics
In this paper, we investigate the commutators of fractional maximal functions on mixed-norm amalgam spaces. Furthermore, we present some new characterizations of Lipschitz functions.
Suixin He, Lihua Zhang, Heng Yang
doaj   +1 more source

General Conditions for Existence of Maximal Elements via the Uncovered Set [PDF]

This paper disentangles the topological assumptions of classical results (e.g., Walker (1977)) on existence of maximal elements from rationality conditions. It is known from the social choice literature that under the standard topological conditions-with
John Duggan
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Commutators for the maximal and sharp functions with weighted Lipschitz functions on weighted Morrey spaces

Demonstratio Mathematica
We study the boundedness of commutators of the Hardy-Littlewood maximal function and the sharp maximal function on weighted Morrey spaces when the symbols of the commutators belong to weighted Lipschitz spaces (weighted Morrey-Campanato spaces). Some new
Zhang Pu, Fan Di
doaj   +1 more source

Posets with maximal Möbius function

Journal of Combinatorial Theory, Series A, 1991
Let P be any finite poset. P is said to be bounded if it contains a unique minimal element \({\hat 0}\) and a unique maximal element \({\hat 1}\). The Möbius function of a bounded poset P is defined by \(\mu(P)=\mu (\hat 0,\hat 1)\). The question about the maximum absolute value of \(\mu(P)\) was posed by \textit{R. Stanley} [Enumerative Combinatorics,
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source