Results 141 to 150 of about 1,683,952 (323)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Weighted Estimates for Maximal Functions Associated to Skeletons [PDF]

, 2019
Andrea Olivo, Ezequiel Rela
openalex   +1 more source

On the regularity of the maximal function of a BV function [PDF]

, 2021
Panu Lahti
openalex   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Local one-sided maximal function on fractional Sobolev spaces [PDF]

, 2019
Abhishek Ghosh, Kalachand Shuin
openalex   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

A characterization of maximal ideals in the Fréchet algebras of holomorphic functions $F^p$ $(1 [PDF]

, 2018
Romeo Meštrović
openalex   +2 more sources

Lebesgue Space Estimates for Spherical Maximal Functions on Heisenberg Groups [PDF]

, 2021
Joris Roos, Andreas Seeger, Rajula Srivastava   +2 more
openalex   +1 more source

Is the maximal function of a Lipschitz function continuous?

, 1999
We examine the action of the maximal operator \(M\) on Lipschitz and Hölder functions in the context of homogeneous spaces. It is shown that in spaces satisfying a so-called annular decay property, \(M\) maps spaces of Hölder type to other spaces of Hölder type (the Hölder index is preserved if small enough).
openaire   +3 more sources