Results 151 to 160 of about 693,697 (314)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Recovery of Muscle Function Following Strength Training in Rowers
Strength training using free weights is performed by athletes in many sports as a means of enhancing performance. However, there is a dearth of research investigating the acute impact of bouts of this form of strength training on muscle function, which ...
Gee, Thomas
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A KKM-RESULT AND AN APPLICATION FOR BINARY AND NON-BINARY CHOICE FUNCTIONS [PDF]
By generalizing the classical Knaster-Kuratowski-Mazurkiewicz Theorem, we obtain a result that provides sufficient conditions to ensure the non-emptiness of several kinds of choice functions. This result generalizes well-known results on the existence of
Begoña Subiza
core
PLoS ONEBackgroundVarious breathing exercises are used to enhance lung function. However, many patients have reported experiencing breathlessness and an increased work of breathing during their use, but evidence supporting this is limited.
Preeyaphorn Songsorn +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Neighborhood Complexes and Generating Functions for Affine Semigroups [PDF]
Given a_{1}; a_{2},...a_{n} in Z^{d}, we examine the set, G, of all nonnegative integer combinations of these ai. In particular, we examine the generating function f(z) = Sum_{b in G}z^{b}.
Herbert E. Scarf, Kevin M. Woods
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Central and peripheral determinants of fatigue in acute hypoxia
, 2011 This thesis was submitted for the degree of Docter of Philosophy and awarded by Brunel University on 24th March 2011.Fatigue is defined as an exercise-induced decrease in maximal voluntary force produced by a muscle. Fatigue may arise from central and/or
Goodall, Stuart
core
On weighted dyadic Carleson's inequalities
Journal of Inequalities and Applications, 2001 We give an alternate proof of weighted dyadic Carleson's inequalities which are essentially proved by Sawyer and Wheeden. We use the Bellman function approach of Nazarov and Treil.
Tachizawa K
doaj