Results 141 to 150 of about 693,697 (314)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
, 2010 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis examined the effect of heat stress, dehydration and exercise on global left ventricular (LV) function and LV twist, untwisting and strain (LV ...
Stöhr, Eric J
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Changes in lower extremity muscle function after 56 days of bed rest
, 2011 Preservation of muscle function, known to decline in microgravity and simulation (bed rest), is important for successful spaceflight missions. Hence, there is great interest in developing interventions to prevent musclefunction loss.
I. Michaelis +11 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
On the choice of most-preferred alternatives
Maximal elements of a binary relation on compact subsets of a metric space define a choice function. Necessary and sufficient conditions are found for: (1) the choice function to have nonempty values and be path independent; (2) the choice function to ...
Kukushkin, Nikolai S.
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Maximal ergodic inequalities for Banach function spaces
, 2016 We analyse the Transfer Principle, which is used to generate weak type maximal inequalities for ergodic operators, and extend it to the general case of σσ-compact locally compact Hausdorff groups acting measure-preservingly on σσ-finite measure spaces ...
De Beer, Richard, Labuschagne, Louis
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Maximizing a Function in a Convex Region
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1959 Summary The problem is considered of maximizing a function in a convex region. to solve this problem a new method is developed, to be called “method of feasible directions”. It is a method of steep ascent. Starting with a feasible solution a sequence of feasible trial solutions with ever-increasing values for the objective function is ...
openaire +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Kakeya maximal function conjecture for semialgebraic mappings
, 2021 The Kakeya maximal function conjecture is a quantitative, single scale formulation of the Kakeya conjecture. Recently, algebraic methods have been leading to progress in the Kakeya family of problems.
Rai Choudhuri, Mukul
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