Results 71 to 80 of about 1,683,952 (323)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Maximal power production as a function of sex and training status

Biology of Sport, 2018
Maximal muscular power is achieved at lower percentages of maximal strength (1RM); however, this notion has not been elucidated based on sex or training status. Therefore, the purpose of this investigation was to examine the influence of sex and training
Ryan M. Miller, Eduardo D. Freitas, Aaron D. Heishman, Japneet Kaur, Karolina J. Koziol, Bianca A. Galletti, Michael G. Bemben   +6 more
doaj   +1 more source

Maximal potentials, maximal singular integrals, and the spherical maximal function [PDF]

Proceedings of the American Mathematical Society, 2014
We introduce a notion of maximal potentials and we prove that they form bounded operators from $L^p$ to the homogeneous Sobolev space $\dot{W}^{1,p}$ for all $n/(n-1)
Hajłasz, Piotr, Liu, Zhuomin
openaire   +2 more sources

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Variation of the Dyadic Maximal Function

International Mathematics Research Notices, 2022
AbstractWe prove that for the dyadic maximal operator $\textrm {M}$ and every locally integrable function $f\in L^1_{{\textrm {loc}}}(\mathbb R^d)$ with bounded variation, also $\textrm {M} f$ is locally integrable and $\mathop {\textrm {var}}\textrm {M} f\leq C_d\mathop {\textrm {var}} f$ for any dimension $d\geq 1$.
openaire   +2 more sources

The Variation of the Fractional Maximal Function of a Radial Function [PDF]

International Mathematics Research Notices, 2017
Abstract In this article, we study the regularity of the non-centered fractional maximal operator $M_{\beta}$. As the main result, we prove that there exists $C(n,\beta)$ such that if $q=n/(n-\beta)$ and $f$ is radial function, then $\|DM_{\beta}f\|_{L^{q}({\mathbb{R}^n})}\leq C(n,\beta)\|Df\|_{L^{1}({\mathbb{R}^n})}$.
Luiro, Hannes, Madrid, Jose
openaire   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Boundedness of the Hardy-Littlewood Maximal Operator and Multilinear Maximal Operator in Weighted Morrey Type Spaces

Journal of Function Spaces, 2014
The aim of this paper is to prove the boundedness of the Hardy-Littlewood maximal operator on weighted Morrey spaces and multilinear maximal operator on multiple weighted Morrey spaces. In particular, the result includes the Komori-Shirai theorem and the
Takeshi Iida
doaj   +1 more source