Results 111 to 120 of about 340,430 (282)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Asymptotic Behavior of a Discrete Nonlinear Oscillator with Damping Dynamical System

Advances in Difference Equations, 2011
We propose a new discrete version of nonlinear oscillator with damping dynamical system governed by a general maximal monotone operator. We show the weak convergence of solutions and their weighted averages to a zero of a maximal monotone operator .
Khatibzadeh Hadi
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Maximal regularity and Hardy spaces

, 2007
In this work, we consider the Cauchy problem for $u' - Au = f$ with $A$ the Laplacian operator on some Riemannian manifolds or a sublapacian on some Lie groups or some second order elliptic operators on a domain.
Auscher, Pascal, Bernicot, Frédéric, Zhao, Jiman   +2 more
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Maximal operators of Fejér means of Walsh-Kaczmarz-Fourier series

Journal of Function Spaces and Applications, 2010
The main aim of this paper is to prove that there exists a martingale f∈ H1/2 such that the maximal Fejér operator with respect to Walsh-Kaczmarz system does not belong to the space L1/2.
Ushangi Goginava, Károly Nagy
doaj   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

On the convergence of Fourier series

International Journal of Mathematics and Mathematical Sciences, 1984
We define the space Bp={f:(−π,π]→R,   f(t)=∑n=0∞cnbn(t),   ∑n=0∞|cn|
Geraldo Soares de Souza
doaj   +1 more source

Maximal norm Hankel operators

Journal of Mathematical Analysis and Applications
A Hankel operator $\mathbf{H}_φ$ on the Hardy space $H^2$ of the unit circle with analytic symbol $φ$ has minimal norm if $\|\mathbf{H}_φ\|=\|φ\|_2$ and maximal norm if $\|\mathbf{H}_φ\| = \|φ\|_\infty$. The Hankel operator $\mathbf{H}_φ$ has both minimal and maximal norm if and only if $|φ|$ is constant almost everywhere on the unit circle or ...
Brevig, Ole Fredrik, Seip, Kristian
openaire   +4 more sources