Results 111 to 120 of about 988,365 (280)
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
An existence result is presented for the dynamical low rank (DLR) approximation for random semi-linear evolutionary equations. The DLR solution approximates the true solution at each time instant by a linear combination of products of deterministic and ...
Nobile, Fabio, Kazashi, Yoshihito
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
THE MAXIMAL RANK OF ELLIPTIC DELSARTE SURFACES
, 2012 Shioda described a method to compute the Lefschetz number of a Delsarte surface. In one of his examples he uses this method to compute the rank of an elliptic curve over k(t).
Heijne, Bas
core +1 more source
, 2008 Suppose that each member of a set A of applicants ranks a subset of a set P of posts in an order of preference, possibly involving ties. A matching isa set of (applicant, post) pairs such that each applicant and each post appears in at most one pair.
Telikepalli Kavitha +4 more
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
基于ANSYS Workbench协同平台的汽车膜片弹簧有限元分析
Jixie chuandong, 2012 Taking a kind diaphragm spring of automobile clutch as an example,a finite element analysis based on ANSYS Workbench is studied and explained.Stress and strain variation regulation of diaphragm spring is obtained by using statics analysis,and each rank ...
金卫东
doaj
, 2013 International Mathematical Forum, Vol. 6, 2011, no.
Maingi, Damian +1 more
openaire +1 more source