Results 121 to 130 of about 6,663,186 (371)

Variable Versus Constant Resistance Squat Training for Lower-Limb Strength and Power: A Systematic Review and Meta-Analysis

Applied Sciences
The superiority of Variable Resistance Training (VRT) over traditional Constant Resistance Training (CRT) for enhancing lower-limb performance is debated, with previous meta-analyses limited by aggregating disparate exercises.
Zhijie Yan, Juncheng Wu, Shengfa Lin, Qi Li, Ruidong Liu   +4 more
doaj   +1 more source

Effects of downhill walking training on aerobic and neuromuscular fitness of young adults

Revista Brasileira de Cineantropometria e Desempenho Humano, 2015
Eccentric exercise training using low intensity-high volume approach has been performed to improve maximal muscle strength and power. The aim of this study was to compare the effects of short-term downhill walking and level walking training on lower limb
Leonardo Coelho Rabello de Lima, Thiago Pires de Oliveira, Felipe Bruno Dias de Oliveira, Fernanda Fioravanti Azank dos Santos, Claudio de Oliveira Assumpção, Camila Coelho Greco, Benedito Sérgio Denadai   +6 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A soothing invisible hand: moderation potentials in optimal control [PDF]

, 2013
A moderation incentive is a continuously differentiable control-dependent cost term that is identically zero on the boundary of the admissible control region, and is subtracted from the `do or die' cost function to reward sub-maximal control utilization ...
Lewis, Debra
core  

Achieving Long-Term Fairness in Submodular Maximization Through Randomization

Submodular function optimization has numerous applications in machine learning and data analysis, including data summarization which aims to identify a concise and diverse set of data points from a large dataset. It is important to implement fairness-aware algorithms when dealing with data items that may contain sensitive attributes like race or gender,
Tang, Shaojie, Yuan, Jing, Mensah-Boateng, Twumasi   +2 more
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Long-Term Surface Water Dynamics Analysis Based on Landsat Imagery and the Google Earth Engine Platform: A Case Study in the Middle Yangtze River Basin

Remote Sensing, 2018
Dynamics of surface water is of great significance to understand the impacts of global changes and human activities on water resources. Remote sensing provides many advantages in monitoring surface water; however, in large scale, the efficiency of ...
Chao Wang, M. Jia, Nengcheng Chen, Wei Wang   +3 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Long-term oncologic outcomes of radiotherapy combined with maximal androgen blockade for localized, high-risk prostate cancer [PDF]

, 2018
Yong Luo, Mingchuan Li, Hengzhi Qi, Jiahui Zhao, Yili Han, Yunhua Lin, Zhu Hou, Yongguang Jiang   +7 more
openalex   +1 more source